4-{4-(3-methylphenyl)-2-[4-(methylsulfanyl)phenyl]-1,3-thiazol-5-yl}pyridin-2-amine

Base Information

Chemical Name:4-{4-(3-methylphenyl)-2-[4-(methylsulfanyl)phenyl]-1,3-thiazol-5-yl}pyridin-2-amine
CAS No.:303162-40-5
Molecular Formula:C₂₂H₁₉N₃S₂
Molecular Weight:389.545
Hs Code.:

Synonyms:4-{4-(3-methylphenyl)-2-[4-(methylsulfanyl)phenyl]-1,3-thiazol-5-yl}pyridin-2-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-{4-(3-methylphenyl)-2-[4-(methylsulfanyl)phenyl]-1,3-thiazol-5-yl}pyridin-2-amine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:: SDS file from LookChem

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Technology Process of 4-{4-(3-methylphenyl)-2-[4-(methylsulfanyl)phenyl]-1,3-thiazol-5-yl}pyridin-2-amine

There total 6 articles about 4-{4-(3-methylphenyl)-2-[4-(methylsulfanyl)phenyl]-1,3-thiazol-5-yl}pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 2-(2-amino-4-pyridyl)-2-bromo-1-(3-methylphenyl)ethanone hydrobromide

: 53550-91-7
4-(methylsulfanyl)benzenecarbothioamide

: 303162-40-5
4-{4-(3-methylphenyl)-2-[4-(methylsulfanyl)phenyl]-1,3-thiazol-5-yl}pyridin-2-amine

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 14h;
DOI:10.1021/jm050165o

Reference yield:

: 303162-37-0
2-(2-tert-butoxycarbonylamino-pyridin-4-yl)-1-(3-methylphenyl)ethanone

: 303162-40-5
4-{4-(3-methylphenyl)-2-[4-(methylsulfanyl)phenyl]-1,3-thiazol-5-yl}pyridin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / Br₂; AcOH / 3 h / 80 °C

2: 71 percent / dimethylformamide / 14 h / 20 °C

With bromine; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm050165o

Reference yield:

: 21384-43-0
1-(3-methylbenzoyl)-2-methylaziridine

: 303162-40-5
4-{4-(3-methylphenyl)-2-[4-(methylsulfanyl)phenyl]-1,3-thiazol-5-yl}pyridin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C

1.2: 81 percent / tetrahydrofuran; hexane / -78 - 20 °C

2.1: 86 percent / Br₂; AcOH / 3 h / 80 °C

3.1: 71 percent / dimethylformamide / 14 h / 20 °C

With n-butyllithium; bromine; acetic acid; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm050165o