(R)-3-(4-methoxyphenyl)-N,N-dimethyl-3-((S)-5-oxo-2,5-dihydrofuran-2-yl)propanethioamide

Base Information

• Chemical Name: (R)-3-(4-methoxyphenyl)-N,N-dimethyl-3-((S)-5-oxo-2,5-dihydrofuran-2-yl)propanethioamide
• CAS No.: 1638616-34-8
• Molecular Formula: C₁₆H₁₉NO₃S
• Molecular Weight: 305.398

Synonyms:(R)-3-(4-methoxyphenyl)-N,N-dimethyl-3-((S)-5-oxo-2,5-dihydrofuran-2-yl)propanethioamide

Chemical Property of (R)-3-(4-methoxyphenyl)-N,N-dimethyl-3-((S)-5-oxo-2,5-dihydrofuran-2-yl)propanethioamide

Chemical Property:

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Technology Process of (R)-3-(4-methoxyphenyl)-N,N-dimethyl-3-((S)-5-oxo-2,5-dihydrofuran-2-yl)propanethioamide

There total 1 articles about (R)-3-(4-methoxyphenyl)-N,N-dimethyl-3-((S)-5-oxo-2,5-dihydrofuran-2-yl)propanethioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C12H15NOS + 2-buten-4-olide (497-23-4) → (R)-3-(4-methoxyphenyl)-N,N-dimethyl-3-((S)-5-oxo-2,5-dihydrofuran-2-yl)propanethioamide (1638616-34-8)

Guidance literature:

With tetrakis(actonitrile)copper(I) hexafluorophosphate; N-Methyldicyclohexylamine; (R)-segphos; In tetrahydrofuran; at 20 ℃; for 24h; stereoselective reaction; Inert atmosphere;

DOI:10.1002/anie.201402332

Reference yield:

(R)-3-(4-methoxyphenyl)-N,N-dimethyl-3-((S)-5-oxo-2,5-dihydrofuran-2-yl)propanethioamide (1638616-34-8) + phenyllithium (591-51-5) → C20H18O4

Guidance literature:

(R)-3-(4-methoxyphenyl)-N,N-dimethyl-3-((S)-5-oxo-2,5-dihydrofuran-2-yl)propanethioamide; With methyl trifluoromethanesulfonate; In tetrahydrofuran;

phenyllithium; With N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 ℃; for 0.5h;

DOI:10.1002/anie.201402332

upstream raw materials:

2-buten-4-olide

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