N-<2-(methylethylidene)-1,4-dioxo-4-(phenylmethoxy)butyl>-L-tryptophan methyl ester

Base Information

Chemical Name:N-<2-(methylethylidene)-1,4-dioxo-4-(phenylmethoxy)butyl>-L-tryptophan methyl ester
CAS No.:164364-48-1
Molecular Formula:C₂₆H₂₈N₂O₅
Molecular Weight:448.519
Hs Code.:

Synonyms:N-<2-(methylethylidene)-1,4-dioxo-4-(phenylmethoxy)butyl>-L-tryptophan methyl ester

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Chemical Property of N-<2-(methylethylidene)-1,4-dioxo-4-(phenylmethoxy)butyl>-L-tryptophan methyl ester

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Technology Process of N-<2-(methylethylidene)-1,4-dioxo-4-(phenylmethoxy)butyl>-L-tryptophan methyl ester

There total 4 articles about N-<2-(methylethylidene)-1,4-dioxo-4-(phenylmethoxy)butyl>-L-tryptophan methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 7524-52-9,26988-71-6,5619-09-0,14907-27-8,41222-70-2,67557-19-1,109492-62-8
(S)-tryptophan methyl ester hydrochloride

: 151927-79-6
2-(2-(benzyloxy)-2-oxoethyl)-3-methylbut-2-enoic acid

: 164364-48-1
N-<2-(methylethylidene)-1,4-dioxo-4-(phenylmethoxy)butyl>-L-tryptophan methyl ester

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 47h;
DOI:10.1021/jm00012a011

Reference yield:

: 74222-68-7
dihydro-3-(methylethylidene)-2,5-furandione

: 164364-48-1
N-<2-(methylethylidene)-1,4-dioxo-4-(phenylmethoxy)butyl>-L-tryptophan methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / CHCl₃ / 72 h / Heating

2: 100 percent / iPr₂NEt, HOBt-H₂O, EDC / dimethylformamide / 47 h / 20 °C

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00012a011

Reference yield:

: 584-27-0
2-isopropylidenesuccinic acid

: 164364-48-1
N-<2-(methylethylidene)-1,4-dioxo-4-(phenylmethoxy)butyl>-L-tryptophan methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / acetyl chloride / 0.33 h / Heating

2: 69 percent / CHCl₃ / 72 h / Heating

3: 100 percent / iPr₂NEt, HOBt-H₂O, EDC / dimethylformamide / 47 h / 20 °C

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; acetyl chloride; In chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00012a011