tert-butyl (4S)-1-methyl-3-<(2S)-2-(4-toluenesulfonyloxy)propionyl>-2-oxoimidazolidine-4-carboxylate

Base Information

Chemical Name:tert-butyl (4S)-1-methyl-3-<(2S)-2-(4-toluenesulfonyloxy)propionyl>-2-oxoimidazolidine-4-carboxylate
CAS No.:143996-80-9
Molecular Formula:C₁₉H₂₆N₂O₇S
Molecular Weight:426.491
Hs Code.:

Synonyms:tert-butyl (4S)-1-methyl-3-<(2S)-2-(4-toluenesulfonyloxy)propionyl>-2-oxoimidazolidine-4-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (4S)-1-methyl-3-<(2S)-2-(4-toluenesulfonyloxy)propionyl>-2-oxoimidazolidine-4-carboxylate

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Technology Process of tert-butyl (4S)-1-methyl-3-<(2S)-2-(4-toluenesulfonyloxy)propionyl>-2-oxoimidazolidine-4-carboxylate

There total 3 articles about tert-butyl (4S)-1-methyl-3-<(2S)-2-(4-toluenesulfonyloxy)propionyl>-2-oxoimidazolidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 83261-13-6
(2S)-2-(4-toluenesulfonyloxy)propionyl chloride

: 83056-79-5
(4S)-1-methyl-2-oxoimidazolidine-4-carboxylic acid t-butyl ester

: 143996-80-9
tert-butyl (4S)-1-methyl-3-<(2S)-2-(4-toluenesulfonyloxy)propionyl>-2-oxoimidazolidine-4-carboxylate

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at -50 ℃; for 0.333333h;
DOI:10.1248/cpb.40.1619

Reference yield:

: 70836-98-5
(S)-2-(p-toluenesulphonyloxy)propionic acid

: 143996-80-9
tert-butyl (4S)-1-methyl-3-<(2S)-2-(4-toluenesulfonyloxy)propionyl>-2-oxoimidazolidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / CHCl₃ / 3 h / Heating

2: 70 percent / potassium tert-butoxide / tetrahydrofuran / 0.33 h / -50 °C

With thionyl chloride; potassium tert-butylate; In tetrahydrofuran; chloroform;
DOI:10.1248/cpb.40.1619

Reference yield:

: tert-butyl (4S)-1-methyl-3-(2-tosyloxypropionyl)-2-oxoimidazolidine-4-carboxylate

: 100-46-9
benzylamine

: 130368-70-6
tert-Butyl (4S)-1-Methyl-3-<(2R)-2-(4-toluenesulfonyloxy)propionyl>-2-oxoimidazolidine-4-carboxylate

: 143996-80-9
tert-butyl (4S)-1-methyl-3-<(2S)-2-(4-toluenesulfonyloxy)propionyl>-2-oxoimidazolidine-4-carboxylate

: tert-Butyl (4S)-3-<(2S)-2-(N-benzylamino)propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate

: 157163-04-7
tert-Butyl (4S)-3-<(2R)-2-(N-benzylamino)propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate

Guidance literature:: With triethylamine; In dimethyl sulfoxide; at 50 ℃; for 36h; Yield given. Yields of byproduct given;
DOI:10.1016/S0040-4039(00)76842-0