[(3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[(2,3-difluoro-4-methoxy-phenyl)methyl]phenyl]-2-(hydroxymethyl)-6-methoxy-tetrahydropyran-2-yl]methanol

Base Information

Chemical Name:[(3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[(2,3-difluoro-4-methoxy-phenyl)methyl]phenyl]-2-(hydroxymethyl)-6-methoxy-tetrahydropyran-2-yl]methanol
CAS No.:1358579-99-3
Molecular Formula:C₄₃H₄₃ClF₂O₈
Molecular Weight:761.259
Hs Code.:

[(3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[(2,3-difluoro-4-methoxy-phenyl)methyl]phenyl]-2-(hydroxymethyl)-6-methoxy-tetrahydropyran-2-yl]methanol

Synonyms:[(3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[(2,3-difluoro-4-methoxy-phenyl)methyl]phenyl]-2-(hydroxymethyl)-6-methoxy-tetrahydropyran-2-yl]methanol

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Chemical Property of [(3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[(2,3-difluoro-4-methoxy-phenyl)methyl]phenyl]-2-(hydroxymethyl)-6-methoxy-tetrahydropyran-2-yl]methanol

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Technology Process of [(3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[(2,3-difluoro-4-methoxy-phenyl)methyl]phenyl]-2-(hydroxymethyl)-6-methoxy-tetrahydropyran-2-yl]methanol

There total 19 articles about [(3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[(2,3-difluoro-4-methoxy-phenyl)methyl]phenyl]-2-(hydroxymethyl)-6-methoxy-tetrahydropyran-2-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: (2R,3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[(2,3-difluoro-4-methoxyphenyl)methyl]phenyl]-2-(hydroxymethyl)-6-methoxytetrahydropyran-2-carbaldehyde

: 1358579-99-3
[(3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[(2,3-difluoro-4-methoxy-phenyl)methyl]phenyl]-2-(hydroxymethyl)-6-methoxy-tetrahydropyran-2-yl]methanol

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 - 30 ℃; for 4h; Inert atmosphere;

Reference yield: 40.0%

: 1358579-96-0
(2S,3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[(2,3-difluoro-4-methoxy-phenyl)methyl]phenyl]-2-(hydroxymethyl)-6-methoxy-tetrahydropyran-2-carbaldehyde

: 1358579-99-3
[(3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[(2,3-difluoro-4-methoxy-phenyl)methyl]phenyl]-2-(hydroxymethyl)-6-methoxy-tetrahydropyran-2-yl]methanol

Guidance literature:: With methanol; sodium tetrahydroborate; In tetrahydrofuran; for 0.333333h;

Reference yield:

: 21739-92-4
5-bromo-2-chlorobenzoic acid

: 1358579-99-3
[(3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[(2,3-difluoro-4-methoxy-phenyl)methyl]phenyl]-2-(hydroxymethyl)-6-methoxy-tetrahydropyran-2-yl]methanol

Guidance literature:: Multi-step reaction with 11 steps

1.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 5 h / 0 - 100 °C

2.1: aluminum (III) chloride / dichloromethane / 16 h / 0 °C

3.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 0.5 h

4.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 16 h

5.1: n-butyllithium / tetrahydrofuran; hexane; toluene / 1 h / -78 °C

5.2: 3 h / -78 °C

6.1: pyridine; dmap / pyridine; ethyl acetate / 16 h

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 0 - 20 °C

8.1: methanol / 1 h

9.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 0.67 h / -78 °C

9.2: 1.5 h / 20 °C

10.1: sodium hydroxide; water / 1,4-dioxane / 70 °C

11.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 0.33 h

With pyridine; methanol; triethylsilane; dmap; aluminum (III) chloride; sodium tetrahydroborate; n-butyllithium; thionyl chloride; oxalyl dichloride; boron trifluoride diethyl etherate; water; sodium hydride; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; hexane; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;