8-nitro-6-{4-[N-methyl-N-(2-phenylethyl)amino]-1-piperidinylcarbonyl}-3,4-dihydrocarbostyril

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Chemical Name:8-nitro-6-{4-[N-methyl-N-(2-phenylethyl)amino]-1-piperidinylcarbonyl}-3,4-dihydrocarbostyril
CAS No.:165591-87-7
Molecular Formula:C₂₄H₂₈N₄O₄
Molecular Weight:436.511
Hs Code.:

Synonyms:8-nitro-6-{4-[N-methyl-N-(2-phenylethyl)amino]-1-piperidinylcarbonyl}-3,4-dihydrocarbostyril

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Chemical Property of 8-nitro-6-{4-[N-methyl-N-(2-phenylethyl)amino]-1-piperidinylcarbonyl}-3,4-dihydrocarbostyril

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Technology Process of 8-nitro-6-{4-[N-methyl-N-(2-phenylethyl)amino]-1-piperidinylcarbonyl}-3,4-dihydrocarbostyril

There total 5 articles about 8-nitro-6-{4-[N-methyl-N-(2-phenylethyl)amino]-1-piperidinylcarbonyl}-3,4-dihydrocarbostyril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 165591-87-7
8-nitro-6-{4-[N-methyl-N-(2-phenylethyl)amino]-1-piperidinylcarbonyl}-3,4-dihydrocarbostyril

Guidance literature:: Multi-step reaction with 3 steps

1.1: AcOH; H₂ / Pt/C / ethanol / 2 h / 40 °C / 760 Torr

2.1: formic acid; H₂O / 1 h / 50 °C

2.2: 66 percent / H₂; HCl / Pd/C / ethanol / 3 h / 40 °C / 760 Torr

3.1: diethylphosphoryl cyanide; Et₃N / dimethylformamide / 0.5 h / 0 °C

With formic acid; diethylphosphoryl cyanide; water; hydrogen; acetic acid; triethylamine; platinum on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm020597o

Reference yield:

: 64-04-0
phenethylamine

: 165591-87-7
8-nitro-6-{4-[N-methyl-N-(2-phenylethyl)amino]-1-piperidinylcarbonyl}-3,4-dihydrocarbostyril

Guidance literature:: Multi-step reaction with 3 steps

1.1: AcOH; H₂ / Pt/C / ethanol / 2 h / 40 °C / 760 Torr

2.1: formic acid; H₂O / 1 h / 50 °C

2.2: 66 percent / H₂; HCl / Pd/C / ethanol / 3 h / 40 °C / 760 Torr

3.1: diethylphosphoryl cyanide; Et₃N / dimethylformamide / 0.5 h / 0 °C

With formic acid; diethylphosphoryl cyanide; water; hydrogen; acetic acid; triethylamine; platinum on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm020597o