(-)-benzyl N-<(αR)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>carbamat

Base Information

Chemical Name:(-)-benzyl N-<(αR)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>carbamat
CAS No.:213686-55-6
Molecular Formula:C₃₃H₄₁NO₆
Molecular Weight:547.692
Hs Code.:

Synonyms:(-)-benzyl N-<(αR)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>carbamat

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Chemical Property of (-)-benzyl N-<(αR)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>carbamat

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Technology Process of (-)-benzyl N-<(αR)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>carbamat

There total 9 articles about (-)-benzyl N-<(αR)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>carbamat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 213595-53-0
(R)-(-)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydrylamine

: 213686-55-6
(-)-benzyl N-<(αR)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>carbamat

Guidance literature:: With triethylamine; In tetrahydrofuran; for 8h; Ambient temperature;
DOI:10.1002/(SICI)1099-0690(199902)1999:2<503::AID-EJOC503>3.0.CO;2-I

Reference yield:

: 207615-45-0
benzaldehyde N-(benzyloxycarbonyl)imine

: 172794-67-1
(4R,5R)-2-(2-Bromo-benzyl)-4,5-bis-(1-methoxy-1-methyl-ethyl)-[1,3]dioxolane

: 213686-55-6
(-)-benzyl N-<(αR)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>carbamat

: 213686-58-9
(+)-benzyl N-<(αS)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>carbamat

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction. Yields of byproduct given; 1.) -105 deg C;
DOI:10.1016/0040-4039(95)01716-U

Reference yield:

: 172794-67-1
(4R,5R)-2-(2-Bromo-benzyl)-4,5-bis-(1-methoxy-1-methyl-ethyl)-[1,3]dioxolane

: 213686-55-6
(-)-benzyl N-<(αR)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>carbamat

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-butyllithium / 1.) hexane, THF, -100 deg C, 15 min, 2.) THF, -85 to -100 deg C, 6 h

2: 68 percent / Na, liquid ammonia / tetrahydrofuran / 0.75 h / -78 °C

3: 81 percent / NEt₃ / tetrahydrofuran / 8 h / Ambient temperature

With n-butyllithium; ammonia; sodium; triethylamine; In tetrahydrofuran;
DOI:10.1002/(SICI)1099-0690(199902)1999:2<503::AID-EJOC503>3.0.CO;2-I