2,2-anhydro-1-(5-O-benzoyl-4-C-benzoyloxymethyl-3-O-benzyl-β-D-threo-pentofuranosyl)thymine

Base Information

Chemical Name:2,2-anhydro-1-(5-O-benzoyl-4-C-benzoyloxymethyl-3-O-benzyl-β-D-threo-pentofuranosyl)thymine
CAS No.:552856-58-3
Molecular Formula:C₃₂H₂₈N₂O₈
Molecular Weight:568.583
Hs Code.:

Synonyms:2,2-anhydro-1-(5-O-benzoyl-4-C-benzoyloxymethyl-3-O-benzyl-β-D-threo-pentofuranosyl)thymine

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Chemical Property of 2,2-anhydro-1-(5-O-benzoyl-4-C-benzoyloxymethyl-3-O-benzyl-β-D-threo-pentofuranosyl)thymine

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Technology Process of 2,2-anhydro-1-(5-O-benzoyl-4-C-benzoyloxymethyl-3-O-benzyl-β-D-threo-pentofuranosyl)thymine

There total 7 articles about 2,2-anhydro-1-(5-O-benzoyl-4-C-benzoyloxymethyl-3-O-benzyl-β-D-threo-pentofuranosyl)thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: C₃₃H₃₂N₂O₁₁S

: 552856-58-3
2,2-anhydro-1-(5-O-benzoyl-4-C-benzoyloxymethyl-3-O-benzyl-β-D-threo-pentofuranosyl)thymine

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1039/b208864a

Reference yield:

: 552856-52-7
5-O-benzoyl-4-C-benzoyloxymethyl-3-O-benzyl-1,2-O-isopropylidene-α-D-erythro-pentofuranose

: 552856-58-3
2,2-anhydro-1-(5-O-benzoyl-4-C-benzoyloxymethyl-3-O-benzyl-β-D-threo-pentofuranosyl)thymine

Guidance literature:: Multi-step reaction with 5 steps

1.1: aq. H₂SO₄ / acetic acid / 18 h / 20 °C

2.1: N,O-bis(trimethylsilyl)acetamide / acetonitrile / 1 h / 0 °C

2.2: trimethylsilyl triflate / acetonitrile / 2 h / 65 °C

3.1: 84 percent / methanolic ammonia / methanol / 0 - 20 °C

4.1: pyridine / CH₂Cl₂ / 0 - 20 °C

5.1: 98 percent / DBU / dimethylformamide / 20 °C

With pyridine; N,O-bis-(trimethylsilyl)-acetamide; sulfuric acid; ammonia; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/b208864a

Reference yield:

: 552856-54-9
1,2-di-O-acetyl-5-O-benzoyl-4-C-benzoyloxymethyl-3-O-benzyl-D-erythro-pentofuranose

: 552856-58-3
2,2-anhydro-1-(5-O-benzoyl-4-C-benzoyloxymethyl-3-O-benzyl-β-D-threo-pentofuranosyl)thymine

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,O-bis(trimethylsilyl)acetamide / acetonitrile / 1 h / 0 °C

1.2: trimethylsilyl triflate / acetonitrile / 2 h / 65 °C

2.1: 84 percent / methanolic ammonia / methanol / 0 - 20 °C

3.1: pyridine / CH₂Cl₂ / 0 - 20 °C

4.1: 98 percent / DBU / dimethylformamide / 20 °C

With pyridine; N,O-bis-(trimethylsilyl)-acetamide; ammonia; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/b208864a