acetic acid (R)-2-(4-methylphenyl)sulfonyl-1-methyl-ethyl ester

Base Information

• Chemical Name: acetic acid (R)-2-(4-methylphenyl)sulfonyl-1-methyl-ethyl ester
• CAS No.: 862249-95-4
• Molecular Formula: C₁₂H₁₆O₄S
• Molecular Weight: 256.323
• Mol file: 862249-95-4.mol

Synonyms:acetic acid (R)-2-(4-methylphenyl)sulfonyl-1-methyl-ethyl ester

Chemical Property of acetic acid (R)-2-(4-methylphenyl)sulfonyl-1-methyl-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of acetic acid (R)-2-(4-methylphenyl)sulfonyl-1-methyl-ethyl ester

There total 2 articles about acetic acid (R)-2-(4-methylphenyl)sulfonyl-1-methyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

Isopropenyl acetate (108-22-5) + 1-(4-methylphenylsulfonyl)propan-2-ol (85870-05-9) → acetic acid (R)-2-(4-methylphenyl)sulfonyl-1-methyl-ethyl ester (862249-95-4)

Guidance literature:

With Candida antarctica lipase B; potassium phosphate; C₃₈H₂₄O₃Ru; In toluene; at 25 ℃; for 20h; optical yield given as %ee; Molecular sieve; Inert atmosphere; Enzymatic reaction;

DOI:10.1016/j.tet.2010.03.069

Reference yield: 79.0%

4-chlorophenyl acetate (876-27-7) + 1-(4-methylphenylsulfonyl)propan-2-ol (85870-05-9) → acetic acid (R)-2-(4-methylphenyl)sulfonyl-1-methyl-ethyl ester (862249-95-4) + 4-chloro-phenol (106-48-9,82344-39-6)

Guidance literature:

With pyridine; Candida antarctica lipase B; Ru2(CO)4(μ-H)[(Ph4C5O)2H]; at 30 ℃; for 72h;

DOI:10.1016/j.tetasy.2005.05.005

Reference yield: 100.0%

acetic acid (R)-2-(4-methylphenyl)sulfonyl-1-methyl-ethyl ester (862249-95-4) → (R)-1-(Toluene-4-sulfonyl)-propan-2-ol

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at 65 ℃; for 1h;

DOI:10.1016/j.tetasy.2005.05.005

upstream raw materials:

4-chlorophenyl acetate

1-(4-methylphenylsulfonyl)propan-2-ol

Isopropenyl acetate