3,5-bis(hydroxymethyl)-4-[4'-{3-(triethylsilyl)propyliminomethyl}benzyloxy]-1-phenylacetylene

Base Information

Chemical Name:3,5-bis(hydroxymethyl)-4-[4'-{3-(triethylsilyl)propyliminomethyl}benzyloxy]-1-phenylacetylene
CAS No.:1373945-33-5
Molecular Formula:C₂₇H₃₇NO₃Si
Molecular Weight:451.681
Hs Code.:

Synonyms:3,5-bis(hydroxymethyl)-4-[4'-{3-(triethylsilyl)propyliminomethyl}benzyloxy]-1-phenylacetylene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,5-bis(hydroxymethyl)-4-[4'-{3-(triethylsilyl)propyliminomethyl}benzyloxy]-1-phenylacetylene

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Technology Process of 3,5-bis(hydroxymethyl)-4-[4'-{3-(triethylsilyl)propyliminomethyl}benzyloxy]-1-phenylacetylene

There total 9 articles about 3,5-bis(hydroxymethyl)-4-[4'-{3-(triethylsilyl)propyliminomethyl}benzyloxy]-1-phenylacetylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.5%

: 1330596-84-3
3,5-bis(hydroxymethyl)-4-(4'-formylbenzyloxy)phenylacetylene

: 17887-09-1
3-(aminopropyl)triethylsilane

: 1373945-33-5
3,5-bis(hydroxymethyl)-4-[4'-{3-(triethylsilyl)propyliminomethyl}benzyloxy]-1-phenylacetylene

Guidance literature:: With aluminum oxide; In tetrahydrofuran; at 20 ℃; for 72h; Inert atmosphere;
DOI:10.1016/j.polymer.2013.11.046

Reference yield:

: 263160-70-9
1-acetoxy-2,6-bis(acetoxymethyl)-4-bromobenzene

: 1373945-33-5
3,5-bis(hydroxymethyl)-4-[4'-{3-(triethylsilyl)propyliminomethyl}benzyloxy]-1-phenylacetylene

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine; copper(l) iodide; triethylamine / 24 h / Reflux; Inert atmosphere

2: lithium hydride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3: hydrogenchloride; water / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

4: potassium carbonate / N,N-dimethyl-formamide / 50 h / 70 °C / Inert atmosphere

5: aluminum oxide / tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

With hydrogenchloride; aluminum oxide; copper(l) iodide; water; lithium hydride; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.polymer.2013.11.046

Reference yield:

: 1234899-27-4
2-acetoxy-1,3-bis(acetoxymethyl)-5-(trimethylsilylethynyl)benzene

: 1373945-33-5
3,5-bis(hydroxymethyl)-4-[4'-{3-(triethylsilyl)propyliminomethyl}benzyloxy]-1-phenylacetylene

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hydride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2: hydrogenchloride; water / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 50 h / 70 °C / Inert atmosphere

4: aluminum oxide / tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

With hydrogenchloride; aluminum oxide; water; lithium hydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.polymer.2013.11.046