2-[2-(1-Piperidinyl)ethyl]pyridine

Base Information

• Chemical Name: 2-[2-(1-Piperidinyl)ethyl]pyridine
• CAS No.: 5452-83-5
• Molecular Formula: C12H18 N2
• Molecular Weight: 190.288
• Hs Code.: 2933990090
• European Community (EC) Number: 226-696-8
• NSC Number: 18995
• UNII: VP2KT79M01
• DSSTox Substance ID: DTXSID9063902
• Nikkaji Number: J51.337G
• Wikidata: Q81991082
• ChEMBL ID: CHEMBL1870588
• Mol file: 5452-83-5.mol

Synonyms:5452-83-5;1-[2-(2-Pyridyl)Ethyl]Piperidine;2-[2-(1-Piperidinyl)ethyl]pyridine;2-(2-Piperidinoethyl)pyridine;2-(2-piperidin-1-ylethyl)pyridine;Pyridine, 2-(2-piperidinoethyl)-;EINECS 226-696-8;2-(2-(1-Piperidinyl)ethyl)pyridine;Pyridine, 2-(2-(1-piperidinyl)ethyl)-;NSC 18995;1-(2-(alpha-Pyridyl)ethyl)piperidine;1-[2-(Pyridin-2-yl)ethyl]piperidine;BRN 0145873;Pyridine, 2-[2-(1-piperidinyl)ethyl]-;MLS002638640;VP2KT79M01;2-(2-(Piperidyl)ethyl)pyridine;1-[2-(2-pyridinyl)ethyl]piperidine;NSC-18995;5-22-09-00372 (Beilstein Handbook Reference);2-[2-(piperidyl)ethyl]pyridine;NSC18995;UNII-VP2KT79M01;1-(2-pyridylethyl)piperidine;SCHEMBL3939455;CHEMBL1870588;DTXSID9063902;HMS3091F09;ICCB1_000126;MFCD00006510;AKOS024319566;2-(2-(Piperidin-1-yl)ethyl)pyridine;1-[2-(.alpha.-Pyridyl)ethyl]piperidine;SMR001548111;LS-131902;FT-0691210;PIPERIDINE, 1-(2-(2-PYRIDYL)ETHYL)-

Chemical Property of 2-[2-(1-Piperidinyl)ethyl]pyridine

Chemical Property:

• Vapor Pressure: 0.00614mmHg at 25°C
• Boiling Point: 272.3°Cat760mmHg
• Flash Point: 123.1°C
• PSA: 16.13000
• Density: 1.006g/cm³
• LogP: 2.04790
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 190.146998583
• Heavy Atom Count: 14
• Complexity: 152

Purity/Quality:

98%min ^*data from raw suppliers

1-[2-(PYRIDIN-2-YL)ETHYL]PIPERIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)CCC2=CC=CC=N2

Technology Process of 2-[2-(1-Piperidinyl)ethyl]pyridine

There total 10 articles about 2-[2-(1-Piperidinyl)ethyl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

piperidine (110-89-4) + 2-vinylpyridine (100-69-6,25014-15-7,27476-03-5,329041-71-6) → 2-[2-(piperidyl)ethyl]pyridine (5452-83-5)

Guidance literature:

With zinc(II) nitrate hexahydrate; In acetonitrile; at 60 ℃; for 12h; Sealed tube; Green chemistry;

DOI:10.1002/cssc.201403154

Reference yield: 79.0%

3-(piperidin-1-yl)propionitrile (3088-41-3) + acetylene (74-86-2,25067-58-7) → 2-[2-(piperidyl)ethyl]pyridine (5452-83-5)

Guidance literature:

(η5-cyclopentadienyl)-η4-cycloocta-1,5-dienecobalt(I); In toluene; at 25 ℃; Irradiation;

DOI:10.1021/jo011032n

Reference yield:

(E)-N-[2-(2-pyridyl)ethenyl]piperidine → 2-[2-(piperidyl)ethyl]pyridine (5452-83-5)

Guidance literature:

palladium on activated charcoal; In tetrahydrofuran; for 48h; under 760 Torr;

DOI:10.1002/(SICI)1099-0682(199907)1999:7<1121::AID-EJIC1121>3.0.CO;2-8

upstream raw materials:

piperidine

2-vinylpyridine

3-(piperidin-1-yl)propionitrile

acetylene

Downstream raw materials:

2-(2-Piperidinoethyl)piperidin

Refernces

• 1、 Ghasemi, Mohammad Hadi,Kowsari, Elaheh. "The catalytic effect of anion-exchanged supported ionic liquid on aza-Michael-type addition". . p. 3691 - 3709. Retrieved 2017/06/20.
• 2、 Abou-Shehada, Sarah,Teasdale, Matthew C.,Bull, Steven D.,Wade, Charles E.,Williams, Jonathan M. J.. "Lewis acid activation of pyridines for nucleophilic aromatic substitution and conjugate addition". . p. 1083 - 1087. Retrieved 2015/03/30.