O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-(1->3)-(di-4,6-O-benzyl-2-nitro-2-deoxy-α-D-galactopyranosyl)-N-(t-butyloxycarbonyl)-L-serine tert-butyl ester

Base Information

Chemical Name:O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-(1->3)-(di-4,6-O-benzyl-2-nitro-2-deoxy-α-D-galactopyranosyl)-N-(t-butyloxycarbonyl)-L-serine tert-butyl ester
CAS No.:944064-81-7
Molecular Formula:C₆₆H₇₈N₂O₁₆
Molecular Weight:1155.35
Hs Code.:

O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-(1->3)-(di-4,6-O-benzyl-2-nitro-2-deoxy-α-D-galactopyranosyl)-N-(t-butyloxycarbonyl)-L-serine tert-butyl ester

Synonyms:O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-(1->3)-(di-4,6-O-benzyl-2-nitro-2-deoxy-α-D-galactopyranosyl)-N-(t-butyloxycarbonyl)-L-serine tert-butyl ester

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Chemical Property of O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-(1->3)-(di-4,6-O-benzyl-2-nitro-2-deoxy-α-D-galactopyranosyl)-N-(t-butyloxycarbonyl)-L-serine tert-butyl ester

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Technology Process of O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-(1->3)-(di-4,6-O-benzyl-2-nitro-2-deoxy-α-D-galactopyranosyl)-N-(t-butyloxycarbonyl)-L-serine tert-butyl ester

There total 7 articles about O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-(1->3)-(di-4,6-O-benzyl-2-nitro-2-deoxy-α-D-galactopyranosyl)-N-(t-butyloxycarbonyl)-L-serine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 944064-80-6
O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-(1->3)-di-4,6-O-benzyl-2-nitro-D-galactal

: 71630-31-4,7738-22-9
N-(tert-butyloxycarbonyl)-L-serine tert-butyl ester

: 944064-81-7
O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-(1->3)-(di-4,6-O-benzyl-2-nitro-2-deoxy-α-D-galactopyranosyl)-N-(t-butyloxycarbonyl)-L-serine tert-butyl ester

Guidance literature:: With potassium tert-butylate; In toluene; for 2h;
DOI:10.1021/jo061670b

Reference yield:

: 132748-02-8
O-(2,3,4,6-tetra-O-benzyl-α,β-D-galactopyranosyl)trichloroacetimidate

: 944064-81-7
O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-(1->3)-(di-4,6-O-benzyl-2-nitro-2-deoxy-α-D-galactopyranosyl)-N-(t-butyloxycarbonyl)-L-serine tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 47 percent / tin (II) triflate / CH₂Cl₂; diethyl ether; acetonitrile / 0.5 h / 20 °C

2.1: tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

3.1: 1.2 g / sodium hydride / dimethylformamide / 18 h / 20 °C

4.1: conc. nitric acid; acetic anhydride / CH₂Cl₂ / 1 h / -30 °C

4.2: 63 percent / triethylamine / CH₂Cl₂ / 0.42 h

5.1: 58 percent / potassium tert-butoxide / toluene / 2 h

With potassium tert-butylate; tetrabutyl ammonium fluoride; nitric acid; acetic anhydride; sodium hydride; tin (II) triflate; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jo061670b

Reference yield:

: 166021-01-8
1,5-anhydro-6-O-triisopropylsilyl-2-deoxy-D-lyxo-hex-1-enitol

: 944064-81-7
O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-(1->3)-(di-4,6-O-benzyl-2-nitro-2-deoxy-α-D-galactopyranosyl)-N-(t-butyloxycarbonyl)-L-serine tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 47 percent / tin (II) triflate / CH₂Cl₂; diethyl ether; acetonitrile / 0.5 h / 20 °C

2.1: tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

3.1: 1.2 g / sodium hydride / dimethylformamide / 18 h / 20 °C

4.1: conc. nitric acid; acetic anhydride / CH₂Cl₂ / 1 h / -30 °C

4.2: 63 percent / triethylamine / CH₂Cl₂ / 0.42 h

5.1: 58 percent / potassium tert-butoxide / toluene / 2 h

With potassium tert-butylate; tetrabutyl ammonium fluoride; nitric acid; acetic anhydride; sodium hydride; tin (II) triflate; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jo061670b