Detomidine hydrochloride

Base Information

• Chemical Name: Detomidine hydrochloride
• CAS No.: 90038-01-0
• Molecular Formula: C₁₂H₁₄N₂*ClH
• Molecular Weight: 222.718
• Hs Code.: 2933290090
• European Community (EC) Number: 682-040-4,933-125-2
• UNII: 95K4LKB6QE
• DSSTox Substance ID: DTXSID7048661
• Wikidata: Q27271799
• NCI Thesaurus Code: C75038
• RXCUI: 48928
• ChEMBL ID: CHEMBL2106210
• Mol file: 90038-01-0.mol

Synonyms:detomidine;detomidine hydrochloride;detomidine monohydrochloride

Chemical Property of Detomidine hydrochloride

Chemical Property:

• Vapor Pressure: 7.83E-06mmHg at 25°C
• Melting Point: 160 °C
• Boiling Point: 386.5 °C at 760 mmHg
• Flash Point: 200.6 °C
• PSA: 28.68000
• LogP: 3.41930
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 222.0923762
• Heavy Atom Count: 15
• Complexity: 181

Purity/Quality:

99%MIN ^*data from raw suppliers

Detomidine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=CC=C1)CC2=CN=CN2)C.Cl
• Uses: α-Adrenoceptor agonist with sedative and analgesic activity. Sedative. Detomidine produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors. Detomidine Hydrochloride is an α-Adrenoceptor agonist with sedative and analgesic activity. Sedative.

Technology Process of Detomidine hydrochloride

There total 1 articles about Detomidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-benzyl-5-(2,3-dimethylphenylhydroxymethyl)imidazole (83902-12-9) → 4(5)-(2,3-dimethylbenzyl)imidazole hydrochloride (90038-01-0)

Guidance literature:

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In ethanol; water; at 75 ℃; for 24h; under 1650.17 Torr;

upstream raw materials:

1-benzyl-5-(2,3-dimethylphenylhydroxymethyl)imidazole

Refernces