2-[2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-eth-(E)-ylidene]-5-[(Z)-(S)-2-methoxymethyl-pyrrolidin-1-ylimino]-pentan-1-ol

Base Information

Chemical Name:2-[2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-eth-(E)-ylidene]-5-[(Z)-(S)-2-methoxymethyl-pyrrolidin-1-ylimino]-pentan-1-ol
CAS No.:276679-39-1
Molecular Formula:C₂₀H₄₀N₂O₃Si
Molecular Weight:384.635
Hs Code.:

Synonyms:2-[2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-eth-(E)-ylidene]-5-[(Z)-(S)-2-methoxymethyl-pyrrolidin-1-ylimino]-pentan-1-ol

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Chemical Property of 2-[2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-eth-(E)-ylidene]-5-[(Z)-(S)-2-methoxymethyl-pyrrolidin-1-ylimino]-pentan-1-ol

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Technology Process of 2-[2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-eth-(E)-ylidene]-5-[(Z)-(S)-2-methoxymethyl-pyrrolidin-1-ylimino]-pentan-1-ol

There total 1 articles about 2-[2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-eth-(E)-ylidene]-5-[(Z)-(S)-2-methoxymethyl-pyrrolidin-1-ylimino]-pentan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 59983-39-0,187035-29-6
(S)-1-amino-2-(methoxymethyl)pyrrolidine

: 276679-37-9
tert-butyl-[2-(6-methoxy-dihydro-pyran-3-ylidene)-propoxy]-dimethyl-silane

: 276679-39-1
2-[2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-eth-(E)-ylidene]-5-[(Z)-(S)-2-methoxymethyl-pyrrolidin-1-ylimino]-pentan-1-ol

Guidance literature:: With toluene-4-sulfonic acid; In benzene; for 48h; Heating;
DOI:10.1021/ja000728f

Reference yield: 100.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 276679-39-1
2-[2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-eth-(E)-ylidene]-5-[(Z)-(S)-2-methoxymethyl-pyrrolidin-1-ylimino]-pentan-1-ol

: [6-(tert-butyl-dimethyl-silanyloxy)-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-methyl-hex-4-enylidene]-(2-methoxymethyl-pyrrolidin-1-yl)-amine

Guidance literature:: With 1H-imidazole; In dichloromethane; for 0.5h;
DOI:10.1021/ja000728f

Reference yield:

: 276679-39-1
2-[2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-eth-(E)-ylidene]-5-[(Z)-(S)-2-methoxymethyl-pyrrolidin-1-ylimino]-pentan-1-ol

: 276679-62-0
(E)-(R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-6-hydroxy-2-((Z)-3-iodo-allyl)-5-methyl-hex-4-enenitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: 100 percent / imidazole / CH₂Cl₂ / 0.5 h

2.1: LDA / tetrahydrofuran; hexane / 24 h / 0 °C

2.2: tetrahydrofuran; hexane / -100 - 0 °C

3.1: 98 percent / magnesium monoperoxyphthalate hexahydrate / methanol; diethyl ether / 0.08 h / 0 °C

4.1: 76 percent / pyridinium*HF / tetrahydrofuran / 0.25 h

With 1H-imidazole; pyridine hydrogenfluoride; magnesium monoperoxyphthalate hexahydrate; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; 1.1: silylation / 2.1: Metallation / 2.2: Alkylation / 3.1: Oxidation / 4.1: desilylation;
DOI:10.1021/ja000728f