2-(3,4-dihydro-2H-pyran-5-yl)-1,3-diphenyl-1,3-diaza-2λ³-phospholidine

Base Information

• Chemical Name: 2-(3,4-dihydro-2H-pyran-5-yl)-1,3-diphenyl-1,3-diaza-2λ³-phospholidine
• CAS No.: 417702-48-8
• Molecular Formula: C₁₉H₂₁N₂OP
• Molecular Weight: 324.362
• Mol file: 417702-48-8.mol

Synonyms:2-(3,4-dihydro-2H-pyran-5-yl)-1,3-diphenyl-1,3-diaza-2λ³-phospholidine

Chemical Property of 2-(3,4-dihydro-2H-pyran-5-yl)-1,3-diphenyl-1,3-diaza-2λ³-phospholidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,4-dihydro-2H-pyran-5-yl)-1,3-diphenyl-1,3-diaza-2λ³-phospholidine

There total 2 articles about 2-(3,4-dihydro-2H-pyran-5-yl)-1,3-diphenyl-1,3-diaza-2λ³-phospholidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N,N'-diphenylethylenediamine (150-61-8) + 5-dibromophosphino-3,4-dihydro-2H-pyran (417702-49-9) → 2-(3,4-dihydro-2H-pyran-5-yl)-1,3-diphenyl-1,3-diaza-2λ3-phospholidine (417702-48-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

DOI:10.1023/A:1012753627608

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → 2-(3,4-dihydro-2H-pyran-5-yl)-1,3-diphenyl-1,3-diaza-2λ3-phospholidine (417702-48-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / PBr₃ / diethyl ether / 12 h / 20 °C

2: 70 percent / Et₃N / tetrahydrofuran / 1 h / 0 - 20 °C

With phosphorus tribromide; triethylamine; In tetrahydrofuran; diethyl ether;

DOI:10.1023/A:1012753627608

Reference yield: 75.0%

N-phenylbenzohydrazonoyl chloride (15424-14-3) + 2-(3,4-dihydro-2H-pyran-5-yl)-1,3-diphenyl-1,3-diaza-2λ3-phospholidine (417702-48-8) → 1-(3-hydroxypropyl)-1,4,6,8-tetraphenyl-1,4,7,8-tetraaza-5-phosphoniaspiro[4.5]deca-6,9-diene chloride

Guidance literature:

With triethylamine; In benzene; at 20 ℃; for 24h;

DOI:10.1023/A:1012753627608

upstream raw materials:

N,N'-diphenylethylenediamine

5-dibromophosphino-3,4-dihydro-2H-pyran

3,4-dihydro-2H-pyran