(E)-5-cyano-2-((1,4-dimethylpiperazin-2-ylidene)amino)-N-phenylbenzamide

Base Information

Chemical Name:(E)-5-cyano-2-((1,4-dimethylpiperazin-2-ylidene)amino)-N-phenylbenzamide
CAS No.:1613465-34-1
Molecular Formula:C₂₀H₂₁N₅O
Molecular Weight:347.42
Hs Code.:

Synonyms:(E)-5-cyano-2-((1,4-dimethylpiperazin-2-ylidene)amino)-N-phenylbenzamide

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Chemical Property of (E)-5-cyano-2-((1,4-dimethylpiperazin-2-ylidene)amino)-N-phenylbenzamide

Chemical Property:

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Technology Process of (E)-5-cyano-2-((1,4-dimethylpiperazin-2-ylidene)amino)-N-phenylbenzamide

There total 5 articles about (E)-5-cyano-2-((1,4-dimethylpiperazin-2-ylidene)amino)-N-phenylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1613465-80-7
2-(chloromethyl)-4-oxo-3-phenyl-3,4-dihydroquinazoline-6-carbonitrile

: 110-70-3
N,N`-dimethylethylenediamine

: 1613465-34-1
(E)-5-cyano-2-((1,4-dimethylpiperazin-2-ylidene)amino)-N-phenylbenzamide

Guidance literature:: With potassium carbonate; In acetonitrile; at 50 ℃;
DOI:10.1021/jm501203v

Reference yield:

: 33348-34-4
4-amino-3-iodobenzonitrile

: 1613465-34-1
(E)-5-cyano-2-((1,4-dimethylpiperazin-2-ylidene)amino)-N-phenylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate; palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene; triethylamine / acetonitrile / 60 °C / Inert atmosphere

2: lithium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

3: triethylamine / dichloromethane / 16 h / 0 - 20 °C

4: trichlorophosphate / dichloromethane / 0.25 h / 150 °C / Microwave irradiation

5: potassium carbonate / N,N-dimethyl-formamide / 1.5 h

With 1,1'-bis-(diphenylphosphino)ferrocene; water; palladium diacetate; potassium carbonate; triethylamine; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 159847-81-1
methyl 2-AMINO-5-CYANOBENZOATE

: 1613465-34-1
(E)-5-cyano-2-((1,4-dimethylpiperazin-2-ylidene)amino)-N-phenylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

2: triethylamine / dichloromethane / 16 h / 0 - 20 °C

3: trichlorophosphate / dichloromethane / 0.25 h / 150 °C / Microwave irradiation

4: potassium carbonate / N,N-dimethyl-formamide / 1.5 h

With water; potassium carbonate; triethylamine; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;