4-<2-(2-amino-6-methyl-4(3H)-oxo-7H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoic acid

Base Information

Chemical Name:4-<2-(2-amino-6-methyl-4(3H)-oxo-7H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoic acid
CAS No.:176208-14-3
Molecular Formula:C₁₆H₁₆N₄O₃
Molecular Weight:312.328
Hs Code.:

Synonyms:4-<2-(2-amino-6-methyl-4(3H)-oxo-7H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoic acid

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Chemical Property of 4-<2-(2-amino-6-methyl-4(3H)-oxo-7H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoic acid

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Technology Process of 4-<2-(2-amino-6-methyl-4(3H)-oxo-7H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoic acid

There total 6 articles about 4-<2-(2-amino-6-methyl-4(3H)-oxo-7H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 176208-13-2
methyl 4-<2-(2-amino-6-methyl-4(3H)-oxo-7H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoate

: 176208-14-3
4-<2-(2-amino-6-methyl-4(3H)-oxo-7H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; for 3h; Ambient temperature;
DOI:10.3987/com-95-7260

Reference yield:

: 2117-11-5
4-pentyn-2-ol

: 176208-14-3
4-<2-(2-amino-6-methyl-4(3H)-oxo-7H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 60 percent / PdCl₂, Ph₃P, CuI / diethylamine / 18 h / Ambient temperature

2: 96 percent / H₂ / 5percent Pd/C / ethanol / 20 h / 2585.7 Torr

3: 75 percent / PCC, NaOAc / CH₂Cl₂ / 12 h

4: 84 percent / 2-methoxy-ethanol / Heating

5: 61 percent / diphenyl ether / 5 h / Heating

6: 88 percent / 1M aq. NaOH / tetrahydrofuran; H₂O / 3 h / Ambient temperature

With sodium hydroxide; copper(l) iodide; hydrogen; sodium acetate; triphenylphosphine; pyridinium chlorochromate; palladium dichloride; palladium on activated charcoal; In tetrahydrofuran; diphenylether; ethanol; dichloromethane; 2-methoxy-ethanol; water; diethylamine;
DOI:10.3987/com-95-7260

Reference yield:

: 619-42-1
4-methoxycarbonylphenyl bromide

: 176208-14-3
4-<2-(2-amino-6-methyl-4(3H)-oxo-7H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 60 percent / PdCl₂, Ph₃P, CuI / diethylamine / 18 h / Ambient temperature

2: 96 percent / H₂ / 5percent Pd/C / ethanol / 20 h / 2585.7 Torr

3: 75 percent / PCC, NaOAc / CH₂Cl₂ / 12 h

4: 84 percent / 2-methoxy-ethanol / Heating

5: 61 percent / diphenyl ether / 5 h / Heating

6: 88 percent / 1M aq. NaOH / tetrahydrofuran; H₂O / 3 h / Ambient temperature

With sodium hydroxide; copper(l) iodide; hydrogen; sodium acetate; triphenylphosphine; pyridinium chlorochromate; palladium dichloride; palladium on activated charcoal; In tetrahydrofuran; diphenylether; ethanol; dichloromethane; 2-methoxy-ethanol; water; diethylamine;
DOI:10.3987/com-95-7260