2-((6-Ethyl-11,12-dihydro-5-phenyldibenzo(a,E)cycloocten-2-yl)oxy)-N,N-dimethyl ethanamine

Base Information

Chemical Name:2-((6-Ethyl-11,12-dihydro-5-phenyldibenzo(a,E)cycloocten-2-yl)oxy)-N,N-dimethyl ethanamine
CAS No.:85850-78-8
Molecular Formula:C₂₈H₃₁NO
Molecular Weight:397.56
Hs Code.:
UNII:9K9P2R185Y
ChEMBL ID:CHEMBL280246

Synonyms:9K9P2R185Y;2-((6-Ethyl-11,12-dihydro-5-phenyldibenzo(a,E)cycloocten-2-yl)oxy)-N,N-dimethyl ethanamine;85850-78-8;UNII-9K9P2R185Y;CHEMBL280246;SCHEMBL5732864;5,6-DIHYDRO-8-(2-(DIMETHYLAMINO)ETHOXY)-12-DIBENZO(A,E)CYCLOOCTENE;DIBENZO(A,E)CYCLOOCTENE, 5,6-DIHYDRO-8-(2-(DIMETHYLAMINO)ETHOXY)-12-;Dibenzo(a,e)cyclooctene, 5,6-dihydro-8-(2-(dimethylamino)ethoxy)-12-ethyl-11-phenyl-;ETHANAMINE, 2-((6-ETHYL-11,12-DIHYDRO-5-PHENYLDIBENZO(A,E)CYCLOOCTEN-2-YL)OXY)-N,N-DIMETHYL-

Suppliers and Price of 2-((6-Ethyl-11,12-dihydro-5-phenyldibenzo(a,E)cycloocten-2-yl)oxy)-N,N-dimethyl ethanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 2-((6-Ethyl-11,12-dihydro-5-phenyldibenzo(a,E)cycloocten-2-yl)oxy)-N,N-dimethyl ethanamine

Chemical Property:

Vapor Pressure:2.87E-11mmHg at 25°C
Boiling Point:528.8°Cat760mmHg
Flash Point:152.1°C
Density:g/cm³
XLogP3:6.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:397.240564612
Heavy Atom Count:30
Complexity:561

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1=C(C2=C(CCC3=CC=CC=C31)C=C(C=C2)OCCN(C)C)C4=CC=CC=C4
Isomeric SMILES:CC/C/1=C(/C2=C(CCC3=CC=CC=C31)C=C(C=C2)OCCN(C)C)\C4=CC=CC=C4

Technology Process of 2-((6-Ethyl-11,12-dihydro-5-phenyldibenzo(a,E)cycloocten-2-yl)oxy)-N,N-dimethyl ethanamine

There total 11 articles about 2-((6-Ethyl-11,12-dihydro-5-phenyldibenzo(a,E)cycloocten-2-yl)oxy)-N,N-dimethyl ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(2-Dimethylamino-ethoxy)-6-ethyl-5-phenyl-5,6,11,12-tetrahydro-dibenzo[a,e]cycloocten-5-ol

: 85850-78-8
[2-((Z)-6-Ethyl-5-phenyl-11,12-dihydro-dibenzo[a,e]cycloocten-2-yloxy)-ethyl]-dimethyl-amine

Guidance literature:: With hydrogenchloride; In ethanol; for 1h; Yield given; Heating;
DOI:10.1021/jm00362a009

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 85850-78-8
[2-((Z)-6-Ethyl-5-phenyl-11,12-dihydro-dibenzo[a,e]cycloocten-2-yloxy)-ethyl]-dimethyl-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) BuLi / 1.) THF, -70 deg C, 1 h, 2.) THF, RT, 18 h

2: conc. HCl / ethanol / 1 h / Heating

With hydrogenchloride; n-butyllithium; In ethanol;
DOI:10.1021/jm00362a009

Reference yield:

: 17910-71-3
2-<2-(3-methoxyphenyl)ethyl>benzoic acid

: 85850-78-8
[2-((Z)-6-Ethyl-5-phenyl-11,12-dihydro-dibenzo[a,e]cycloocten-2-yloxy)-ethyl]-dimethyl-amine

Guidance literature:: Multi-step reaction with 10 steps

1: LiAlH₄ / diethyl ether; tetrahydrofuran / 4 h / Heating

2: thionyl chloride / toluene / 1 h / 80 °C

3: ethanol; H₂O / 12 h / Heating

4: aq. KOH / ethanol / 3 h / Heating

5: 1.) LDA / 1.) hexane, THF, -70 deg C, 1.5 h, 2.) hexane, THF, from -70 deg C to RT

6: 55 percent / P₂O₅, MeSO₃H / 1 h / Ambient temperature

7: 90 percent / pyridine hydrochloride / 0.5 h / 210 °C

8: 68 percent / K₂CO₃ / acetone; dimethylformamide / 18 h / Heating

9: 1.) BuLi / 1.) THF, -70 deg C, 1 h, 2.) THF, RT, 18 h

10: conc. HCl / ethanol / 1 h / Heating

With hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; methanesulfonic acid; pyridine hydrochloride; phosphorus pentoxide; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; ethanol; water; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/jm00362a009