Antibiotics from Streptomyces coeruleorubidus

Base Information

Chemical Name:Antibiotics from Streptomyces coeruleorubidus
CAS No.:71214-33-0
Molecular Formula:C₂₇H₃₀NO₁₀*Cl
Molecular Weight:563.989
Hs Code.:
European Community (EC) Number:245-723-4
NSC Number:301724,257457,249333,83142,304419,82151
UN Number:2811
NCI Thesaurus Code:C1583
RXCUI:81992
ChEMBL ID:CHEMBL158918

Synonyms:Cerubidine;Dauno Rubidomycine;Dauno-Rubidomycine;Daunoblastin;Daunoblastine;Daunomycin;Daunorubicin;Daunorubicin Hydrochloride;Hydrochloride, Daunorubicin;NSC 82151;NSC-82151;NSC82151;Rubidomycin;Rubomycin

Suppliers and Price of Antibiotics from Streptomyces coeruleorubidus

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Antibiotics from Streptomyces coeruleorubidus

Chemical Property:

Vapor Pressure:6.13E-25mmHg at 25°C
Boiling Point:770°C at 760 mmHg
Flash Point:419.5°C
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:4
Exact Mass:563.1558238
Heavy Atom Count:39
Complexity:960
Transport DOT Label:Poison

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)C)O)N)O.Cl
Isomeric SMILES:CC1C(C(CC(O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)C)O)N)O.Cl
Recent ClinicalTrials:Selinexor With Combination With Induction/Consolidation Therapy in Acute Myeloid Leukemia Patients
Recent EU Clinical Trials:A Phase 1B/2 Study To Evaluate The Safety And Efficacy of PF-04449913, An Oral Hedgehog Inhibitor, In Combination With Intensive Chemotherapy, Low Dose ARA-C Or Decitabine In Patients With Acute Myeloid Leukemia Or High-Risk Myelodysplastic Syndrome

Technology Process of Antibiotics from Streptomyces coeruleorubidus

There total 6 articles about Antibiotics from Streptomyces coeruleorubidus which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6605-27-2
methyl-3-acetamido-2,3,6-tridesoxy-α-D-lyxo-hexopyranoside

: 23541-50-6,56390-08-0,63950-07-2,67463-64-3,70629-85-5,71214-33-0,72402-72-3,76793-43-6,76820-60-5
7-O-(3-amino-2,3,6-tridesoxy-α-D-lyxo-hexopyranosyl)daunomycinone

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / barium hydroxide hydrate / H₂O / 20 h / Heating

2: 77 percent / CH₂Cl₂ / 1 h / 20 °C

3: 81 percent / pyridine / 3 h / 0 °C

4: acetic acid / H₂O / 24 h / Heating

With pyridine; barium hydroxide monohydrate; acetic acid; In dichloromethane; water;
DOI:10.1016/S0008-6215(00)84673-X

Reference yield:

: 76793-38-9
methyl-3-amino-2,3,6-tridesoxy-α-D-lyxo-hexopyranoside

: 23541-50-6,56390-08-0,63950-07-2,67463-64-3,70629-85-5,71214-33-0,72402-72-3,76793-43-6,76820-60-5
7-O-(3-amino-2,3,6-tridesoxy-α-D-lyxo-hexopyranosyl)daunomycinone

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / CH₂Cl₂ / 1 h / 20 °C

2: 81 percent / pyridine / 3 h / 0 °C

3: acetic acid / H₂O / 24 h / Heating

With pyridine; acetic acid; In dichloromethane; water;
DOI:10.1016/S0008-6215(00)84673-X

Reference yield:

: 76793-39-0
methyl-2,3,6-tridesoxy-3-trifluoroacetamido-α-D-lyxo-hexopyranoside

: 23541-50-6,56390-08-0,63950-07-2,67463-64-3,70629-85-5,71214-33-0,72402-72-3,76793-43-6,76820-60-5
7-O-(3-amino-2,3,6-tridesoxy-α-D-lyxo-hexopyranosyl)daunomycinone

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / pyridine / 3 h / 0 °C

2: acetic acid / H₂O / 24 h / Heating

With pyridine; acetic acid; In water;
DOI:10.1016/S0008-6215(00)84673-X