5-(7-fluoro-6-(2-(3-fluoroazetidin-1-yl)ethyl)-11H-indolo[3,2-c][1,5]naphthyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Base Information

Chemical Name:5-(7-fluoro-6-(2-(3-fluoroazetidin-1-yl)ethyl)-11H-indolo[3,2-c][1,5]naphthyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide
CAS No.:1621887-57-7
Molecular Formula:C₃₇H₃₁F₃N₆O₄S
Molecular Weight:712.752
Hs Code.:

5-(7-fluoro-6-(2-(3-fluoroazetidin-1-yl)ethyl)-11H-indolo[3,2-c][1,5]naphthyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Synonyms:5-(7-fluoro-6-(2-(3-fluoroazetidin-1-yl)ethyl)-11H-indolo[3,2-c][1,5]naphthyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Chemical Property of 5-(7-fluoro-6-(2-(3-fluoroazetidin-1-yl)ethyl)-11H-indolo[3,2-c][1,5]naphthyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Technology Process of 5-(7-fluoro-6-(2-(3-fluoroazetidin-1-yl)ethyl)-11H-indolo[3,2-c][1,5]naphthyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

There total 1 articles about 5-(7-fluoro-6-(2-(3-fluoroazetidin-1-yl)ethyl)-11H-indolo[3,2-c][1,5]naphthyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 690257-76-2
3-fluoroazetidine

: 1621888-80-9
3-chloro-N-(6-chloro-2-(4-fluoro-1H-indol-2-yl)pyridin-3-yl)propanamide

: 1621705-60-9
(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethanesulfonamido)benzofuran-5-yl)boronic acid

: 1621887-55-5
5-(11-fluoro-6-(2-(3-fluoroazetidin-1-yl)ethyl)pyrido[3',2':4,5]pyrimido[1,6-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

: 1621887-57-7
5-(7-fluoro-6-(2-(3-fluoroazetidin-1-yl)ethyl)-11H-indolo[3,2-c][1,5]naphthyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: 3-chloro-N-(6-chloro-2-(4-fluoro-1H-indol-2-yl)pyridin-3-yl)propanamide; With trifluoromethylsulfonic anhydride; Triphenylphosphine oxide; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;

3-fluoroazetidine; With triethylamine; In N,N-dimethyl-formamide; at 70 ℃; for 2h; Inert atmosphere;

(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethanesulfonamido)benzofuran-5-yl)boronic acid; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; XPhos; In 1,4-dioxane; water; at 110 ℃; for 6h; Inert atmosphere;