Technology Process of (2E,7E)-(4R,5S,6R)-5-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethyl-4-methyl-deca-2,7-dienal
There total 13 articles about (2E,7E)-(4R,5S,6R)-5-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethyl-4-methyl-deca-2,7-dienal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Dess-Martin periodane;
In
dichloromethane;
DOI:10.1021/ol0521329
- Guidance literature:
-
Multi-step reaction with 12 steps
1: TBHP; Ti(O-iPr)4; D-tartaric acid diethyl ester / -23 °C
2: 62 percent / CuI / diethyl ether / -50 - -40 °C
3: 52 percent / RuCl2(PPh3)3 / benzene
4: 76 percent / benzene / Heating
5: 84 percent / NaH / tetrahydrofuran
6: 94 percent / DIBAL-H
7: 91 percent / triethylamine
8: 84 percent / 1,3-dithiane; BF3*Et2O
9: 89 percent / PDC / CH2Cl2
10: 92 percent / benzene
11: 97 percent / DIBAL-H
12: 98 percent / Dess-Martin periodinane / CH2Cl2
With
1,3 dithiane; titanium(IV) isopropylate; tert.-butylhydroperoxide; copper(l) iodide; dipyridinium dichromate; tris(triphenylphosphine)ruthenium(II) chloride; diethyl (2S,3S)-tartrate; boron trifluoride diethyl etherate; sodium hydride; diisobutylaluminium hydride; Dess-Martin periodane; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane; benzene;
4: Horner-Wittig reaction / 12: Dess-Martin oxidation;
DOI:10.1021/ol0521329
- Guidance literature:
-
Multi-step reaction with 13 steps
1: 90 percent / DIBAL-H / CH2Cl2 / -78 °C
2: TBHP; Ti(O-iPr)4; D-tartaric acid diethyl ester / -23 °C
3: 62 percent / CuI / diethyl ether / -50 - -40 °C
4: 52 percent / RuCl2(PPh3)3 / benzene
5: 76 percent / benzene / Heating
6: 84 percent / NaH / tetrahydrofuran
7: 94 percent / DIBAL-H
8: 91 percent / triethylamine
9: 84 percent / 1,3-dithiane; BF3*Et2O
10: 89 percent / PDC / CH2Cl2
11: 92 percent / benzene
12: 97 percent / DIBAL-H
13: 98 percent / Dess-Martin periodinane / CH2Cl2
With
1,3 dithiane; titanium(IV) isopropylate; tert.-butylhydroperoxide; copper(l) iodide; dipyridinium dichromate; tris(triphenylphosphine)ruthenium(II) chloride; diethyl (2S,3S)-tartrate; boron trifluoride diethyl etherate; sodium hydride; diisobutylaluminium hydride; Dess-Martin periodane; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane; benzene;
5: Horner-Wittig reaction / 13: Dess-Martin oxidation;
DOI:10.1021/ol0521329
