(S,E)-methyl 3-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzo[d]isoxazol-7-ylcarbamate

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Chemical Name:(S,E)-methyl 3-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzo[d]isoxazol-7-ylcarbamate
CAS No.:1430216-10-6
Molecular Formula:C₂₉H₂₃ClN₈O₅
Molecular Weight:599.005
Hs Code.:

Synonyms:(S,E)-methyl 3-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzo[d]isoxazol-7-ylcarbamate

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Chemical Property of (S,E)-methyl 3-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzo[d]isoxazol-7-ylcarbamate

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Technology Process of (S,E)-methyl 3-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzo[d]isoxazol-7-ylcarbamate

There total 6 articles about (S,E)-methyl 3-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzo[d]isoxazol-7-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 942316-73-6
(2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-prop-2-enoic acid

: 1430217-46-1
(S)-methyl 3-(1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzo[d]isoxazol-7-ylcarbamate

: 1430216-10-6
(S,E)-methyl 3-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzo[d]isoxazol-7-ylcarbamate

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In chloroform; ethyl acetate; for 1.5h; Cooling with ice;

Reference yield:

: 1430217-43-8
methyl 3-cyano-2-fluorophenylcarbamate

: 1430216-10-6
(S,E)-methyl 3-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzo[d]isoxazol-7-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: acetylhydroxamic acid; potassium carbonate / water; N,N-dimethyl-formamide / 24 h / 40 °C

2: pyridine; trichlorophosphate / dichloromethane / 1 h / Cooling with ice

3: morpholine / N,N-dimethyl-formamide / 1.5 h / Enzymatic reaction

4: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / chloroform; ethyl acetate / 1.5 h / Cooling with ice

With morpholine; pyridine; acetylhydroxamic acid; potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In dichloromethane; chloroform; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 873697-68-8
3-amino-2-fluorobenzonitrile

: 1430216-10-6
(S,E)-methyl 3-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzo[d]isoxazol-7-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / dichloromethane / 24 h / 0 °C

2: acetylhydroxamic acid; potassium carbonate / water; N,N-dimethyl-formamide / 24 h / 40 °C

3: pyridine; trichlorophosphate / dichloromethane / 1 h / Cooling with ice

4: morpholine / N,N-dimethyl-formamide / 1.5 h / Enzymatic reaction

5: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / chloroform; ethyl acetate / 1.5 h / Cooling with ice

With morpholine; pyridine; acetylhydroxamic acid; potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In dichloromethane; chloroform; water; ethyl acetate; N,N-dimethyl-formamide;