3-Hydroxy-5-hydroxymethyl-benzoic acid

Base Information

Chemical Name:3-Hydroxy-5-hydroxymethyl-benzoic acid
CAS No.:816449-71-5
Molecular Formula:C₈H₈O₄
Molecular Weight:168.149
Hs Code.:
DSSTox Substance ID:DTXSID901280979

Synonyms:3-hydroxy-5-hydroxymethyl-benzoic acid;816449-71-5;SCHEMBL1401774;JZPTVPKKKYRWLI-UHFFFAOYSA-N;DTXSID901280979;3-hydroxy-5-(hydroxymethyl)benzoic acid

Suppliers and Price of 3-Hydroxy-5-hydroxymethyl-benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-Hydroxy-5-hydroxymethyl-benzoic acid

Chemical Property:

XLogP3:0.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:168.04225873
Heavy Atom Count:12
Complexity:168

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=C(C=C(C=C1C(=O)O)O)CO

Technology Process of 3-Hydroxy-5-hydroxymethyl-benzoic acid

There total 1 articles about 3-Hydroxy-5-hydroxymethyl-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 268232-16-2
3-hydroxy-5-hydroxymethylbenzoic acid methyl ester

: 816449-71-5
3-hydroxy-5-(hydroxymethyl)benzoic acid

Guidance literature:: With lithium hydroxide; In methanol; water; at 20 ℃; for 2h;
DOI:10.1021/ja2087147

Reference yield:

: 816449-71-5
3-hydroxy-5-(hydroxymethyl)benzoic acid

: methyl 3-(bromomethyl)-5-hydroxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / 24 h / Reflux

2: triphenylphosphine; carbon tetrabromide / dichloromethane / 3 h

With carbon tetrabromide; sulfuric acid; triphenylphosphine; In dichloromethane;
DOI:10.1002/chem.201503548

Reference yield:

: 816449-71-5
3-hydroxy-5-(hydroxymethyl)benzoic acid

: methyl 3-((1,3-dioxoisoindolin-2-yl)methyl)-5-hydroxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / 24 h / Reflux

2: triphenylphosphine; carbon tetrabromide / dichloromethane / 3 h

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

With carbon tetrabromide; sulfuric acid; potassium carbonate; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.201503548