Technology Process of 4-(benzylamino)-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-one
There total 6 articles about 4-(benzylamino)-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
benzyl benzyl(2-(1-methyl-1H-indole-2-carbonyl)cyclopropyl)carbamate;
With
trifluoroacetic acid;
In
acetonitrile;
at 20 ℃;
for 1.5h;
Inert atmosphere;
With
palladium on activated charcoal; hydrogen;
In
ethanol;
at 20 ℃;
Inert atmosphere;
DOI:10.1002/chem.201102583
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: boron trifluoride diethyl etherate / dichloromethane / -20 - 0 °C / Inert atmosphere
2.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 1 h / 0 °C / Inert atmosphere
3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C / Inert atmosphere
4.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
4.2: 2 h / -78 °C / Inert atmosphere
4.3: 2.33 h / -78 - -20 °C / Inert atmosphere
5.1: trifluoroacetic acid / acetonitrile / 1.5 h / 20 °C / Inert atmosphere
5.2: 20 °C / Inert atmosphere
With
dmap; n-butyllithium; boron trifluoride diethyl etherate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
5.1: Nazarov cyclization;
DOI:10.1002/chem.201102583
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 1 h / 0 °C / Inert atmosphere
2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
3.2: 2 h / -78 °C / Inert atmosphere
3.3: 2.33 h / -78 - -20 °C / Inert atmosphere
4.1: trifluoroacetic acid / acetonitrile / 1.5 h / 20 °C / Inert atmosphere
4.2: 20 °C / Inert atmosphere
With
dmap; n-butyllithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
4.1: Nazarov cyclization;
DOI:10.1002/chem.201102583
