(S)-2-Benzyloxy-dodecanoic acid (1R,2R,3S,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

Base Information

• Chemical Name: (S)-2-Benzyloxy-dodecanoic acid (1R,2R,3S,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester
• CAS No.: 88376-71-0
• Molecular Formula: C₄₃H₅₉NO₅S
• Molecular Weight: 702.011
• Mol file: 88376-71-0.mol

Synonyms:(S)-2-Benzyloxy-dodecanoic acid (1R,2R,3S,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

Chemical Property of (S)-2-Benzyloxy-dodecanoic acid (1R,2R,3S,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-Benzyloxy-dodecanoic acid (1R,2R,3S,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

There total 2 articles about (S)-2-Benzyloxy-dodecanoic acid (1R,2R,3S,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Iododecane (2050-77-3) + Benzyloxy-acetic acid (1R,2R,3S,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester (88494-64-8) → (S)-2-Benzyloxy-dodecanoic acid (1R,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester (88376-71-0) + (S)-2-Benzyloxy-dodecanoic acid (1R,2R,3S,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester (88376-71-0)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium cyclohexylisopropylamide; Yield given. Multistep reaction. Yields of byproduct given; 1.) -80 deg C, THF-HMPT 2.) -63 deg C;

Reference yield:

Iododecane (2050-77-3) + Benzyloxy-acetic acid (1R,2R,3S,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester (88494-64-8) → (S)-2-Benzyloxy-dodecanoic acid (1R,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester (88376-71-0) + (S)-2-Benzyloxy-dodecanoic acid (1R,2R,3S,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester (88376-71-0)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium cyclohexylisopropylamide; Yield given. Multistep reaction. Yields of byproduct given; 1.) -80 deg C, THF-HMPT 2.) -63 deg C;

Reference yield: 96.0%

(S)-2-Benzyloxy-dodecanoic acid (1R,2R,3S,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester (88376-71-0) → (S)-2-(benzyloxy)dodecan-1-ol (85514-83-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

upstream raw materials:

Iododecane

Benzyloxy-acetic acid (1R,2R,3S,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

Downstream raw materials:

(S)-2-(benzyloxy)dodecan-1-ol