Technology Process of 7-(4-chlorophenyl)-7-phenylheptanoic acid (4-methoxyphenyl)amide
There total 5 articles about 7-(4-chlorophenyl)-7-phenylheptanoic acid (4-methoxyphenyl)amide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 100 percent / H2; formic acid / Pd/C / ethanol / 18 h
2: 65 percent / oxalyl chloride; DMSO; diisopropylethylamine / CH2Cl2 / -78 - 20 °C
3: 72 percent / sodium hypochlorite; phosphate monobasic buffer; 2-methyl-2-butene / H2O; 2-methyl-propan-2-ol / 2 h / 20 °C
4: 76 percent / diisopropylethylamine; PyBOP / CH2Cl2 / 0.5 h / 20 °C
With
sodium hypochlorite; formic acid; 2-methyl-but-2-ene; oxalyl dichloride; phosphate monobasic buffer; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
ethanol; dichloromethane; water; tert-butyl alcohol;
2: Swern oxidation;
DOI:10.1016/j.bmc.2005.03.004
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: BuLi / tetrahydrofuran / 1 h / 20 °C
1.2: 37 percent / tetrahydrofuran / 3 h / 0 °C
2.1: 100 percent / H2; formic acid / Pd/C / ethanol / 18 h
3.1: 65 percent / oxalyl chloride; DMSO; diisopropylethylamine / CH2Cl2 / -78 - 20 °C
4.1: 72 percent / sodium hypochlorite; phosphate monobasic buffer; 2-methyl-2-butene / H2O; 2-methyl-propan-2-ol / 2 h / 20 °C
5.1: 76 percent / diisopropylethylamine; PyBOP / CH2Cl2 / 0.5 h / 20 °C
With
sodium hypochlorite; n-butyllithium; formic acid; 2-methyl-but-2-ene; oxalyl dichloride; phosphate monobasic buffer; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; water; tert-butyl alcohol;
3.1: Swern oxidation;
DOI:10.1016/j.bmc.2005.03.004
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: BuLi / tetrahydrofuran / 1 h / 20 °C
1.2: 37 percent / tetrahydrofuran / 3 h / 0 °C
2.1: 100 percent / H2; formic acid / Pd/C / ethanol / 18 h
3.1: 65 percent / oxalyl chloride; DMSO; diisopropylethylamine / CH2Cl2 / -78 - 20 °C
4.1: 72 percent / sodium hypochlorite; phosphate monobasic buffer; 2-methyl-2-butene / H2O; 2-methyl-propan-2-ol / 2 h / 20 °C
5.1: 76 percent / diisopropylethylamine; PyBOP / CH2Cl2 / 0.5 h / 20 °C
With
sodium hypochlorite; n-butyllithium; formic acid; 2-methyl-but-2-ene; oxalyl dichloride; phosphate monobasic buffer; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; water; tert-butyl alcohol;
3.1: Swern oxidation;
DOI:10.1016/j.bmc.2005.03.004
