3-(4-carboxymethylsulfanyl-2,5-dichloro-phenyl)-acrylic acid tert-butyl ester

Base Information

Chemical Name:3-(4-carboxymethylsulfanyl-2,5-dichloro-phenyl)-acrylic acid tert-butyl ester
CAS No.:208512-39-4
Molecular Formula:C₁₅H₁₆Cl₂O₄S
Molecular Weight:363.262
Hs Code.:

3-(4-carboxymethylsulfanyl-2,5-dichloro-phenyl)-acrylic acid <i>tert</i>-butyl ester

Synonyms:3-(4-carboxymethylsulfanyl-2,5-dichloro-phenyl)-acrylic acid tert-butyl ester

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Chemical Property of 3-(4-carboxymethylsulfanyl-2,5-dichloro-phenyl)-acrylic acid tert-butyl ester

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Technology Process of 3-(4-carboxymethylsulfanyl-2,5-dichloro-phenyl)-acrylic acid tert-butyl ester

There total 9 articles about 3-(4-carboxymethylsulfanyl-2,5-dichloro-phenyl)-acrylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 208512-43-0
3-(2,5-dichloro-4-methoxycarbonylmethylsulfanyl-phenyl)-acrylic acid tert-butyl ester

: 208512-39-4
3-(4-carboxymethylsulfanyl-2,5-dichloro-phenyl)-acrylic acid tert-butyl ester

Guidance literature:: With sodium hydroxide; at 20 ℃; for 1.5h;
DOI:10.1016/S0968-0896(02)00336-X

Reference yield:

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 208512-39-4
3-(4-carboxymethylsulfanyl-2,5-dichloro-phenyl)-acrylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / Pd(OAc)3; PPh₃; Bu₃N / dimethylformamide / 3 h / 80 °C

2: 75 percent / dimethylformamide / 1 h / 20 °C

3: 92 percent / aq. NaOH / 1.5 h / 20 °C

With sodium hydroxide; palladium(III) acetate; tributyl-amine; triphenylphosphine; In N,N-dimethyl-formamide; 1: Heck reaction;
DOI:10.1016/S0968-0896(02)00336-X

Reference yield:

: 583-78-8
2,5-dichlorophenol

: 208512-39-4
3-(4-carboxymethylsulfanyl-2,5-dichloro-phenyl)-acrylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 86 percent / I₂; AgSO₄ / CH₂Cl₂ / 24 h

2: DABCO / dimethylformamide / 1 h / 20 °C

3: 13.0 g / 2 h / 220 °C

4: 81 percent / aq. KOH / ethanol / 3 h / Heating

5: 90 percent / Et₃N / CH₂Cl₂ / 1.5 h / 20 °C

6: 50 percent / Pd(OAc)3; PPh₃; Bu₃N / dimethylformamide / 4 h / 80 °C

7: 92 percent / aq. NaOH / 1.5 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; potassium hydroxide; sodium hydroxide; silver(II) sulfate; palladium(III) acetate; tributyl-amine; iodine; triethylamine; triphenylphosphine; In ethanol; dichloromethane; N,N-dimethyl-formamide; 3: Newman-Kwart rearrangement / 6: Heck reaction;
DOI:10.1016/S0968-0896(02)00336-X