4-[2-(3-cyano-4-fluorophenyl)ethyl]-1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}piperidin-4-yl acetate

Base Information

Chemical Name:4-[2-(3-cyano-4-fluorophenyl)ethyl]-1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}piperidin-4-yl acetate
CAS No.:1428477-37-5
Molecular Formula:C₂₅H₂₅FN₆O₃
Molecular Weight:476.51
Hs Code.:

Synonyms:4-[2-(3-cyano-4-fluorophenyl)ethyl]-1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}piperidin-4-yl acetate

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Chemical Property of 4-[2-(3-cyano-4-fluorophenyl)ethyl]-1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}piperidin-4-yl acetate

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Technology Process of 4-[2-(3-cyano-4-fluorophenyl)ethyl]-1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}piperidin-4-yl acetate

There total 8 articles about 4-[2-(3-cyano-4-fluorophenyl)ethyl]-1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}piperidin-4-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428477-34-2
2-fluoro-5-[2-(4-hydroxy-1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}piperidin-4-yl)ethyl]benzonitrile

: 108-24-7
acetic anhydride

: 1428477-37-5
4-[2-(3-cyano-4-fluorophenyl)ethyl]-1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}piperidin-4-yl acetate

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

: 185132-51-8
4-hydroxy-4-trimethylsilanylethynylpiperidine-1-carboxylic acid tert-butyl ester

: 1428477-37-5
4-[2-(3-cyano-4-fluorophenyl)ethyl]-1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}piperidin-4-yl acetate

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / 1,4-dioxane / 48 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 12 h / 5 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 5 °C

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrabutyl ammonium fluoride; triphenylphosphine / tetrahydrofuran / 3 h / 60 °C / Sealed tube; Inert atmosphere

5: palladium on activated charcoal; hydrogen / methanol / 12 h / 760.05 Torr

6: dmap / dichloromethane / 12 h / 20 °C

With hydrogenchloride; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; tetrabutyl ammonium fluoride; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1428477-37-5
4-[2-(3-cyano-4-fluorophenyl)ethyl]-1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}piperidin-4-yl acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

1.2: 1 h / -78 °C

2.1: hydrogenchloride / 1,4-dioxane / 48 h / 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 12 h / 5 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 5 °C

5.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrabutyl ammonium fluoride; triphenylphosphine / tetrahydrofuran / 3 h / 60 °C / Sealed tube; Inert atmosphere

6.1: palladium on activated charcoal; hydrogen / methanol / 12 h / 760.05 Torr

7.1: dmap / dichloromethane / 12 h / 20 °C

With hydrogenchloride; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; palladium on activated charcoal; tetrabutyl ammonium fluoride; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;