2-((1S)-2-{[1-(4-fluorophenyl)-1H-indazol-4-yl]oxy}-1-methylethyl)-1H-isoindole-1,3(2H)-dione

Base Information

• Chemical Name: 2-((1S)-2-{[1-(4-fluorophenyl)-1H-indazol-4-yl]oxy}-1-methylethyl)-1H-isoindole-1,3(2H)-dione
• CAS No.: 934987-50-5
• Molecular Formula: C₂₄H₁₈FN₃O₃
• Molecular Weight: 415.424
• Mol file: 934987-50-5.mol

Synonyms:2-((1S)-2-{[1-(4-fluorophenyl)-1H-indazol-4-yl]oxy}-1-methylethyl)-1H-isoindole-1,3(2H)-dione

Chemical Property of 2-((1S)-2-{[1-(4-fluorophenyl)-1H-indazol-4-yl]oxy}-1-methylethyl)-1H-isoindole-1,3(2H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((1S)-2-{[1-(4-fluorophenyl)-1H-indazol-4-yl]oxy}-1-methylethyl)-1H-isoindole-1,3(2H)-dione

There total 6 articles about 2-((1S)-2-{[1-(4-fluorophenyl)-1H-indazol-4-yl]oxy}-1-methylethyl)-1H-isoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-fluorophenyl)-1H-indazol-4-ol (934986-88-6) + (+)-(S)-2-phthalimidopropyl toluene-p-sulphonate (88722-24-1) → 2-((1S)-2-{[1-(4-fluorophenyl)-1H-indazol-4-yl]oxy}-1-methylethyl)-1H-isoindole-1,3(2H)-dione (934987-50-5)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

Reference yield:

1-(4-fluorophenyl)-4-methoxy-1H-indazole (934986-87-5) → 2-((1S)-2-{[1-(4-fluorophenyl)-1H-indazol-4-yl]oxy}-1-methylethyl)-1H-isoindole-1,3(2H)-dione (934987-50-5)

Guidance literature:

Multi-step reaction with 2 steps

1: boron tribromide / dichloromethane / 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 2 h / 100 °C

With boron tribromide; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

phthalic anhydride (85-44-9) → 2-((1S)-2-{[1-(4-fluorophenyl)-1H-indazol-4-yl]oxy}-1-methylethyl)-1H-isoindole-1,3(2H)-dione (934987-50-5)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / toluene / Heating / reflux

2: pyridine / 20 °C

3: caesium carbonate / N,N-dimethyl-formamide / 2 h / 100 °C

With caesium carbonate; N-ethyl-N,N-diisopropylamine; In pyridine; N,N-dimethyl-formamide; toluene;

upstream raw materials:

1-(4-fluorophenyl)-1H-indazol-4-ol

(+)-(S)-2-phthalimidopropyl toluene-p-sulphonate

phthalic anhydride

1-(4-fluorophenyl)-4-methoxy-1H-indazole

Downstream raw materials:

((1S)-2-{[1-(4-fluorophenyl)-1H-indazol-4-yl]oxy}-1-methylethyl)amine