3-[5-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-5-methyl-[1,2,4]oxadiazole

Base Information

Chemical Name:3-[5-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-5-methyl-[1,2,4]oxadiazole
CAS No.:1345042-04-7
Molecular Formula:C₁₈H₁₅ClN₄O
Molecular Weight:338.796
Hs Code.:

Synonyms:3-[5-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-5-methyl-[1,2,4]oxadiazole

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Chemical Property of 3-[5-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-5-methyl-[1,2,4]oxadiazole

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Technology Process of 3-[5-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-5-methyl-[1,2,4]oxadiazole

There total 7 articles about 3-[5-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-5-methyl-[1,2,4]oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1345041-83-9
5-(4-chlorophenyl)-N-hydroxy-1-phenyl-4,5-dihydro-1H-pyrazole-3-carboxamidine

: 108-24-7
acetic anhydride

: 1345042-04-7
3-[5-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-5-methyl-[1,2,4]oxadiazole

Guidance literature:: With pyridine; at 0 - 100 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.08.061

Reference yield:

: 5-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester

: 1345042-04-7
3-[5-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-5-methyl-[1,2,4]oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium hydroxide / tetrahydrofuran; water / 50 - 60 °C

2: oxalyl dichloride / N,N-dimethyl-formamide / 0.33 h / 0 °C

3: hydroxylamine hydrochloride; sodium carbonate / methanol / 6 h / 25 - 30 °C

4: pyridine / 0 - 100 °C / Inert atmosphere

With pyridine; oxalyl dichloride; hydroxylamine hydrochloride; sodium carbonate; ammonium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.08.061

Reference yield:

: 133678-11-2
ethyl 2-oxo-4-(p-chlorophenyl)but-3-enoate

: 1345042-04-7
3-[5-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-5-methyl-[1,2,4]oxadiazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 2 h / 25 - 30 °C / Inert atmosphere

1.2: 10 h / Inert atmosphere; Reflux

2.1: ammonium hydroxide / tetrahydrofuran; water / 50 - 60 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / 0.33 h / 0 °C

4.1: hydroxylamine hydrochloride; sodium carbonate / methanol / 6 h / 25 - 30 °C

5.1: pyridine / 0 - 100 °C / Inert atmosphere

With pyridine; oxalyl dichloride; hydroxylamine hydrochloride; sodium carbonate; ammonium hydroxide; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.08.061