Technology Process of (1S)-<2-(Phenylsulfonyl)-2-<(trimethylsilyl)methyl>cyclopropyl>acetonitrile
There total 9 articles about (1S)-<2-(Phenylsulfonyl)-2-<(trimethylsilyl)methyl>cyclopropyl>acetonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
15-crown-5;
In
dimethyl sulfoxide;
Ambient temperature;
DOI:10.1021/jo00034a050
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 30percent hydrogen peroxide, glacial acetic acid / 2 h / 100 °C
2: 1. n-butyllithium / 1. Et2O, -78 deg C, 20 min; 2. Et2O, -78 deg C to r.t.
3: Et3N / CH2Cl2 / Ambient temperature
4: n-butyllithium, diisopropylamine / tetrahydrofuran; hexane / a.) -78 deg C to r.t., b.) r.t., 3 h
5: 83 percent / boron trifluoride etherate / CH2Cl2; various solvent(s) / Ambient temperature
6: 95 percent / Et3N / CH2Cl2 / 1 h / Ambient temperature
7: 85 percent / 15-crown-5 / dimethylsulfoxide / Ambient temperature
With
n-butyllithium; 15-crown-5; boron trifluoride diethyl etherate; dihydrogen peroxide; acetic acid; triethylamine; diisopropylamine;
In
tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo00034a050
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1. n-butyllithium / 1. Et2O, -78 deg C, 20 min; 2. Et2O, -78 deg C to r.t.
2: Et3N / CH2Cl2 / Ambient temperature
3: n-butyllithium, diisopropylamine / tetrahydrofuran; hexane / a.) -78 deg C to r.t., b.) r.t., 3 h
4: 83 percent / boron trifluoride etherate / CH2Cl2; various solvent(s) / Ambient temperature
5: 95 percent / Et3N / CH2Cl2 / 1 h / Ambient temperature
6: 85 percent / 15-crown-5 / dimethylsulfoxide / Ambient temperature
With
n-butyllithium; 15-crown-5; boron trifluoride diethyl etherate; triethylamine; diisopropylamine;
In
tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo00034a050
