4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-3-isopropyl-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid trifluoroacetate

Base Information

Chemical Name:4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-3-isopropyl-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid trifluoroacetate
CAS No.:1364613-77-3
Molecular Formula:C₂HF₃O₂*C₃₅H₃₅Cl₂F₂N₃O₄
Molecular Weight:784.607
Hs Code.:

4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-3-isopropyl-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid trifluoroacetate

Synonyms:4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-3-isopropyl-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid trifluoroacetate

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Chemical Property of 4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-3-isopropyl-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid trifluoroacetate

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Technology Process of 4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-3-isopropyl-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid trifluoroacetate

There total 2 articles about 4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-3-isopropyl-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1364616-11-4
4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-3-isopropyl-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid methyl ester

: 76-05-1
trifluoroacetic acid

: 1364613-77-3
4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-3-isopropyl-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid trifluoroacetate

Guidance literature:: 4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-3-isopropyl-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid methyl ester; With potassium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

trifluoroacetic acid;

Reference yield:

: 1229705-05-8
4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino}-3-methoxybenzoic acid methyl ester

: 1364613-77-3
4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-3-isopropyl-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / dichloromethane / 50 - 70 °C

2: potassium hydroxide / tetrahydrofuran; methanol / 20 °C

With acetic acid; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane;