5-chloro-2-methoxy-N-(2-{4-[2-(2-methoxy-ethoxy)-ethoxy]-3-sulfamoyl-phenyl}-ethyl)-benzamide

Base Information

• Chemical Name: 5-chloro-2-methoxy-N-(2-{4-[2-(2-methoxy-ethoxy)-ethoxy]-3-sulfamoyl-phenyl}-ethyl)-benzamide
• CAS No.: 181272-13-9
• Molecular Formula: C₂₁H₂₇ClN₂O₇S
• Molecular Weight: 486.974

Synonyms:5-chloro-2-methoxy-N-(2-{4-[2-(2-methoxy-ethoxy)-ethoxy]-3-sulfamoyl-phenyl}-ethyl)-benzamide

Chemical Property of 5-chloro-2-methoxy-N-(2-{4-[2-(2-methoxy-ethoxy)-ethoxy]-3-sulfamoyl-phenyl}-ethyl)-benzamide

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Technology Process of 5-chloro-2-methoxy-N-(2-{4-[2-(2-methoxy-ethoxy)-ethoxy]-3-sulfamoyl-phenyl}-ethyl)-benzamide

There total 5 articles about 5-chloro-2-methoxy-N-(2-{4-[2-(2-methoxy-ethoxy)-ethoxy]-3-sulfamoyl-phenyl}-ethyl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-2-methoxybenzoic acid (3438-16-2) + 5-(2-amino-ethyl)-2-[2-(2-methoxy-ethoxy)-ethoxy]-benzenesulfonamide; hydrochloride → 5-chloro-2-methoxy-N-(2-{4-[2-(2-methoxy-ethoxy)-ethoxy]-3-sulfamoyl-phenyl}-ethyl)-benzamide (181272-13-9)

Guidance literature:

With TEA; 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1021/jm000985v

Reference yield:

2-Methoxy-5-(2-(2,2,2-trifluoroacetamido)ethyl)benzenesulfonamide (125960-59-0) → 5-chloro-2-methoxy-N-(2-{4-[2-(2-methoxy-ethoxy)-ethoxy]-3-sulfamoyl-phenyl}-ethyl)-benzamide (181272-13-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 85 percent / dimethylformamide / 3 h

2: 95 percent / BBr₃ / CH₂Cl₂ / 5 h / 20 °C

3: K₂CO₃ / dimethylformamide / 3 h / 80 °C

4: 5.5N aq. HCl / methanol / 8 h / Heating

5: N,N'-carbonyldiimidazole; TEA / tetrahydrofuran / 12 h / 20 °C

With hydrogenchloride; TEA; boron tribromide; potassium carbonate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm000985v

Reference yield:

(E)-N-(3-(N-((dimethylamino)methylene)sulfamoyl)-4-methoxyphenethyl)-2,2,2-trifluoroacetamide → 5-chloro-2-methoxy-N-(2-{4-[2-(2-methoxy-ethoxy)-ethoxy]-3-sulfamoyl-phenyl}-ethyl)-benzamide (181272-13-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / BBr₃ / CH₂Cl₂ / 5 h / 20 °C

2: K₂CO₃ / dimethylformamide / 3 h / 80 °C

3: 5.5N aq. HCl / methanol / 8 h / Heating

4: N,N'-carbonyldiimidazole; TEA / tetrahydrofuran / 12 h / 20 °C

With hydrogenchloride; TEA; boron tribromide; potassium carbonate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm000985v

upstream raw materials:

5-chloro-2-methoxybenzoic acid

2-Methoxy-5-(2-(2,2,2-trifluoroacetamido)ethyl)benzenesulfonamide

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