[(2-chloro-5-dimethylamino-phenyl)-(3,4-dimethoxy-benzenesulfonyl)-amino]-acetic acid

Base Information

• Chemical Name: [(2-chloro-5-dimethylamino-phenyl)-(3,4-dimethoxy-benzenesulfonyl)-amino]-acetic acid
• CAS No.: 952194-68-2
• Molecular Formula: C₁₈H₂₁ClN₂O₆S
• Molecular Weight: 428.894
• Mol file: 952194-68-2.mol

Synonyms:[(2-chloro-5-dimethylamino-phenyl)-(3,4-dimethoxy-benzenesulfonyl)-amino]-acetic acid

Chemical Property of [(2-chloro-5-dimethylamino-phenyl)-(3,4-dimethoxy-benzenesulfonyl)-amino]-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(2-chloro-5-dimethylamino-phenyl)-(3,4-dimethoxy-benzenesulfonyl)-amino]-acetic acid

There total 4 articles about [(2-chloro-5-dimethylamino-phenyl)-(3,4-dimethoxy-benzenesulfonyl)-amino]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

[(2-chloro-5-dimethylamino-phenyl)-(3,4-dimethoxy-benzenesulfonyl)-amino]-acetic acid tert-butyl ester (952194-67-1) → [(2-chloro-5-dimethylamino-phenyl)-(3,4-dimethoxy-benzenesulfonyl)-amino]-acetic acid (952194-68-2)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

N1,N1-dimethyl-4-chloro-m-phenylenediamine (53666-60-7) → [(2-chloro-5-dimethylamino-phenyl)-(3,4-dimethoxy-benzenesulfonyl)-amino]-acetic acid (952194-68-2)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 48 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 80 °C

3: triethylsilane; trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With pyridine; triethylsilane; potassium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

N-(2-chloro-5-dimethylamino-phenyl)-3,4-dimethoxy-benzenesulfonamide (952194-66-0) → [(2-chloro-5-dimethylamino-phenyl)-(3,4-dimethoxy-benzenesulfonyl)-amino]-acetic acid (952194-68-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 80 °C

2: triethylsilane; trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With triethylsilane; potassium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

[(2-chloro-5-dimethylamino-phenyl)-(3,4-dimethoxy-benzenesulfonyl)-amino]-acetic acid tert-butyl ester

N-(2-chloro-5-dimethylamino-phenyl)-3,4-dimethoxy-benzenesulfonamide

N-(4-chloro-3-nitrophenyl)-N,N-dimethylamine

N¹,N¹-dimethyl-4-chloro-m-phenylenediamine