acetic acid 2-acetoxy-2-[3-(allyl-methyl-carbamoyl)-5-chlorocarbonyl-2,4,6-triiodo-phenylcarbamoyl]-ethyl ester

Base Information

• Chemical Name: acetic acid 2-acetoxy-2-[3-(allyl-methyl-carbamoyl)-5-chlorocarbonyl-2,4,6-triiodo-phenylcarbamoyl]-ethyl ester
• CAS No.: 946506-09-8
• Molecular Formula: C₁₉H₁₈ClI₃N₂O₇
• Molecular Weight: 802.528

Synonyms:acetic acid 2-acetoxy-2-[3-(allyl-methyl-carbamoyl)-5-chlorocarbonyl-2,4,6-triiodo-phenylcarbamoyl]-ethyl ester

Chemical Property of acetic acid 2-acetoxy-2-[3-(allyl-methyl-carbamoyl)-5-chlorocarbonyl-2,4,6-triiodo-phenylcarbamoyl]-ethyl ester

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Technology Process of acetic acid 2-acetoxy-2-[3-(allyl-methyl-carbamoyl)-5-chlorocarbonyl-2,4,6-triiodo-phenylcarbamoyl]-ethyl ester

There total 3 articles about acetic acid 2-acetoxy-2-[3-(allyl-methyl-carbamoyl)-5-chlorocarbonyl-2,4,6-triiodo-phenylcarbamoyl]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

3-(allyl-methyl-carbamoyl)-5-amino-2,4,6-triiodo-benzoyl chloride (946506-01-0) + 3-chloro-3-oxopropan-1,2-diyl diacetate (69698-48-2) → acetic acid 2-acetoxy-2-[3-(allyl-methyl-carbamoyl)-5-chlorocarbonyl-2,4,6-triiodo-phenylcarbamoyl]-ethyl ester (946506-09-8)

Guidance literature:

In N,N-dimethyl acetamide; at 20 ℃; for 19h;

Reference yield: 56.0%

3-(allyl-methyl-carbamoyl)-5-amino-2,4,6-triiodo-benzoyl chloride (946506-01-0) → acetic acid 2-acetoxy-2-[3-(allyl-methyl-carbamoyl)-5-chlorocarbonyl-2,4,6-triiodo-phenylcarbamoyl]-ethyl ester (946506-09-8)

Guidance literature:

In dimethylacetamide (DMA); at 20 ℃;

Reference yield:

2,4,6-triiodo-5-aminoisophthalic acid (35453-19-1) → acetic acid 2-acetoxy-2-[3-(allyl-methyl-carbamoyl)-5-chlorocarbonyl-2,4,6-triiodo-phenylcarbamoyl]-ethyl ester (946506-09-8)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 1,2-dichloro-ethane / 6 h / 85 °C

2: tetrahydrofuran / 18 h / 50 °C

3: N,N-dimethyl acetamide / 18 h / 20 °C

With thionyl chloride; In tetrahydrofuran; N,N-dimethyl acetamide; 1,2-dichloro-ethane;

DOI:10.1016/j.tetlet.2011.04.010

upstream raw materials:

3-(allyl-methyl-carbamoyl)-5-amino-2,4,6-triiodo-benzoyl chloride

3-chloro-3-oxopropan-1,2-diyl diacetate

2,4,6-triiodo-5-aminoisophthalic acid

Downstream raw materials:

acetic acid 2-acetoxy-2-(3-(allylmethylcarbamoyl)-5-{4,7-bis-[3-(allylmethylcarbamoyl)-5-(2,3-diacetoxypropionylamino)-2,4.6-triiodobenzoyl]-[1,4,7]triazonane-1-carbonyl}-2,4.6-triiodophenylcarbamoyl)ethyl ester

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