(3R,4R)-4-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)-1-(phenylcarbamoyl)pyrrolidine-3-carboxylic acid

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Chemical Name:(3R,4R)-4-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)-1-(phenylcarbamoyl)pyrrolidine-3-carboxylic acid
CAS No.:1033880-42-0
Molecular Formula:C₃₁H₄₁N₇O₆
Molecular Weight:607.71
Hs Code.:

Synonyms:(3R,4R)-4-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)-1-(phenylcarbamoyl)pyrrolidine-3-carboxylic acid

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Chemical Property of (3R,4R)-4-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)-1-(phenylcarbamoyl)pyrrolidine-3-carboxylic acid

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Technology Process of (3R,4R)-4-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)-1-(phenylcarbamoyl)pyrrolidine-3-carboxylic acid

There total 2 articles about (3R,4R)-4-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)-1-(phenylcarbamoyl)pyrrolidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1033881-37-6
(3R,4R)-4-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)pyrrolidine-3-carboxylic acid

: 103-71-9
phenyl isocyanate

: 1033880-42-0
(3R,4R)-4-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)-1-(phenylcarbamoyl)pyrrolidine-3-carboxylic acid

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 0.5h;

Reference yield:

: 1033880-40-8
C₂₈H₄₄N₆O₅

: 103-71-9
phenyl isocyanate

: 1033880-42-0
(3R,4R)-4-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)-1-(phenylcarbamoyl)pyrrolidine-3-carboxylic acid

Guidance literature:: C₂₈H₄₄N₆O₅; phenyl isocyanate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 18h;

With trifluoroacetic acid; In dichloromethane;

Reference yield: 38.0%

: 3-amino-2-hydroxy-hexanoic acid {[(dimethylcarbamoyl-phenyl-methyl)-carbamoyl]-methyl}-amide

: 1033880-42-0
(3R,4R)-4-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)-1-(phenylcarbamoyl)pyrrolidine-3-carboxylic acid

: 1033881-40-1
(3R,4R)-4-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)-N₃-((3S)-1-(2-((S)-2-(dimethylamino)-2-oxo-1-phenylethylamino)-2-oxoethylamino)-2-hydroxy-1-oxohexan-3-yl)-N₁-phenylpyrrolidine-1,3-dicarboxamide

Guidance literature:: (3R,4R)-4-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)-1-(phenylcarbamoyl)pyrrolidine-3-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 0.166667h;

3-amino-2-hydroxy-hexanoic acid {[(dimethylcarbamoyl-phenyl-methyl)-carbamoyl]-methyl}-amide; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 2h;