(S)-octanedioic acid (1-benzyl-2-oxo-2-pyrrolidin-1-yl-ethyl)amide trityloxy-amide

Base Information

Chemical Name:(S)-octanedioic acid (1-benzyl-2-oxo-2-pyrrolidin-1-yl-ethyl)amide trityloxy-amide
CAS No.:449728-90-9
Molecular Formula:C₄₀H₄₅N₃O₄
Molecular Weight:631.815
Hs Code.:

Synonyms:(S)-octanedioic acid (1-benzyl-2-oxo-2-pyrrolidin-1-yl-ethyl)amide trityloxy-amide

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Chemical Property of (S)-octanedioic acid (1-benzyl-2-oxo-2-pyrrolidin-1-yl-ethyl)amide trityloxy-amide

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Technology Process of (S)-octanedioic acid (1-benzyl-2-oxo-2-pyrrolidin-1-yl-ethyl)amide trityloxy-amide

There total 4 articles about (S)-octanedioic acid (1-benzyl-2-oxo-2-pyrrolidin-1-yl-ethyl)amide trityloxy-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3946-32-5
suberic acid monomethyl ester

: 449728-90-9
(S)-octanedioic acid (1-benzyl-2-oxo-2-pyrrolidin-1-yl-ethyl)amide trityloxy-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / iPr₂NEt; BOP-Cl / CH₂Cl₂

2: 80 percent / aq. LiOH / tetrahydrofuran / 20 °C

3: NMM / tetrahydrofuran

4: 320 mg / NMM / tetrahydrofuran / 2.25 h

With 4-methyl-morpholine; lithium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm0208119

Reference yield:

: 31938-11-1
O-tritylhydroxylamine

: 449728-90-9
(S)-octanedioic acid (1-benzyl-2-oxo-2-pyrrolidin-1-yl-ethyl)amide trityloxy-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / iPr₂NEt; BOP-Cl / CH₂Cl₂

2: 80 percent / aq. LiOH / tetrahydrofuran / 20 °C

3: NMM / tetrahydrofuran

4: 320 mg / NMM / tetrahydrofuran / 2.25 h

With 4-methyl-morpholine; lithium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm0208119

Reference yield:

: 449729-22-0
methyl 8–oxo–8-((trityloxy)amino)octanoate

: 449728-90-9
(S)-octanedioic acid (1-benzyl-2-oxo-2-pyrrolidin-1-yl-ethyl)amide trityloxy-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / aq. LiOH / tetrahydrofuran / 20 °C

2: NMM / tetrahydrofuran

3: 320 mg / NMM / tetrahydrofuran / 2.25 h

With 4-methyl-morpholine; lithium hydroxide; In tetrahydrofuran;
DOI:10.1021/jm0208119