(R)-3-(tert-Butyl-diphenyl-silanyloxy)-butyric acid (R)-2-((R)-2-{(R)-2-[(R)-2-((R)-2-carboxy-1-methyl-ethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethoxycarbonyl}-1-methyl-ethoxycarbonyl)-1-methyl-ethyl ester

Base Information

Chemical Name:(R)-3-(tert-Butyl-diphenyl-silanyloxy)-butyric acid (R)-2-((R)-2-{(R)-2-[(R)-2-((R)-2-carboxy-1-methyl-ethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethoxycarbonyl}-1-methyl-ethoxycarbonyl)-1-methyl-ethyl ester
CAS No.:178246-97-4
Molecular Formula:C₄₀H₅₆O₁₃Si
Molecular Weight:772.962
Hs Code.:

(R)-3-(tert-Butyl-diphenyl-silanyloxy)-butyric acid (R)-2-((R)-2-{(R)-2-[(R)-2-((R)-2-carboxy-1-methyl-ethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethoxycarbonyl}-1-methyl-ethoxycarbonyl)-1-methyl-ethyl ester

Synonyms:(R)-3-(tert-Butyl-diphenyl-silanyloxy)-butyric acid (R)-2-((R)-2-{(R)-2-[(R)-2-((R)-2-carboxy-1-methyl-ethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethoxycarbonyl}-1-methyl-ethoxycarbonyl)-1-methyl-ethyl ester

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Chemical Property of (R)-3-(tert-Butyl-diphenyl-silanyloxy)-butyric acid (R)-2-((R)-2-{(R)-2-[(R)-2-((R)-2-carboxy-1-methyl-ethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethoxycarbonyl}-1-methyl-ethoxycarbonyl)-1-methyl-ethyl ester

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Technology Process of (R)-3-(tert-Butyl-diphenyl-silanyloxy)-butyric acid (R)-2-((R)-2-{(R)-2-[(R)-2-((R)-2-carboxy-1-methyl-ethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethoxycarbonyl}-1-methyl-ethoxycarbonyl)-1-methyl-ethyl ester

There total 11 articles about (R)-3-(tert-Butyl-diphenyl-silanyloxy)-butyric acid (R)-2-((R)-2-{(R)-2-[(R)-2-((R)-2-carboxy-1-methyl-ethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethoxycarbonyl}-1-methyl-ethoxycarbonyl)-1-methyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 178246-96-3
(R)-3-(tert-Butyl-diphenyl-silanyloxy)-butyric acid (R)-2-((R)-2-{(R)-2-[(R)-2-((R)-2-benzyloxycarbonyl-1-methyl-ethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethoxycarbonyl}-1-methyl-ethoxycarbonyl)-1-methyl-ethyl ester

: 178246-97-4
(R)-3-(tert-Butyl-diphenyl-silanyloxy)-butyric acid (R)-2-((R)-2-{(R)-2-[(R)-2-((R)-2-carboxy-1-methyl-ethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethoxycarbonyl}-1-methyl-ethoxycarbonyl)-1-methyl-ethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1002/hlca.19960790311

Reference yield:

: 178246-94-1
(R)-3-(tert-Butyl-diphenyl-silanyloxy)-butyric acid (R)-2-((R)-2-benzyloxycarbonyl-1-methyl-ethoxycarbonyl)-1-methyl-ethyl ester

: 178246-97-4
(R)-3-(tert-Butyl-diphenyl-silanyloxy)-butyric acid (R)-2-((R)-2-{(R)-2-[(R)-2-((R)-2-carboxy-1-methyl-ethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethoxycarbonyl}-1-methyl-ethoxycarbonyl)-1-methyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) HF*pyridine; 2.) pyridine / 1.) CH₂Cl₂, 0 deg C, 20 min; 2.) CH₂Cl₂, -78 deg C, then rt. for hours on end

2: 85 percent / H₂ / 10percent Pd/C / methanol

With pyridine; hydrogen; pyridine hydrogenfluoride; palladium on activated charcoal; In methanol;
DOI:10.1002/hlca.19960790311

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 178246-97-4
(R)-3-(tert-Butyl-diphenyl-silanyloxy)-butyric acid (R)-2-((R)-2-{(R)-2-[(R)-2-((R)-2-carboxy-1-methyl-ethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethoxycarbonyl}-1-methyl-ethoxycarbonyl)-1-methyl-ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 79 percent / 1H-imidazole, 4-dimethylaminopyridine / dimethylformamide / 14 h / Ambient temperature

2: 74 percent / KOH / ethanol / 18 h / 0 - 20 °C

3: oxalyl chloride / CH₂Cl₂ / Ambient temperature

4: pyridine / CH₂Cl₂ / -15 °C / for hours on end at rt.

5: 99 percent / H₂ / 10percent Pd/C / methanol / 24 h

6: oxalyl chloride / CH₂Cl₂ / Ambient temperature

7: pyridine / CH₂Cl₂ / -78 °C / for hours on end at rt.

8: 1.) HF*pyridine; 2.) pyridine / 1.) CH₂Cl₂, 0 deg C, 20 min; 2.) CH₂Cl₂, -78 deg C, then rt. for hours on end

9: 85 percent / H₂ / 10percent Pd/C / methanol

With pyridine; 1H-imidazole; dmap; potassium hydroxide; oxalyl dichloride; hydrogen; pyridine hydrogenfluoride; palladium on activated charcoal; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19960790311