<<2α(R),3β>-1S,2S>-1-(2-methyl-3-phenyloxiranyl)-1,2-propanediol

Base Information

• Chemical Name: <<2α(R),3β>-1S,2S>-1-(2-methyl-3-phenyloxiranyl)-1,2-propanediol
• CAS No.: 67505-10-6
• Molecular Formula: C₁₂H₁₆O₃
• Molecular Weight: 208.257
• Mol file: 67505-10-6.mol

Synonyms:<<2α(R),3β>-1S,2S>-1-(2-methyl-3-phenyloxiranyl)-1,2-propanediol

Chemical Property of <<2α(R),3β>-1S,2S>-1-(2-methyl-3-phenyloxiranyl)-1,2-propanediol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of <<2α(R),3β>-1S,2S>-1-(2-methyl-3-phenyloxiranyl)-1,2-propanediol

There total 2 articles about <<2α(R),3β>-1S,2S>-1-(2-methyl-3-phenyloxiranyl)-1,2-propanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(2S,3R)-2,3-Dihydroxy-4-methyl-5-phenylpent-4-ene (67470-70-6) → 2-Methyl-1,2-propanediol (558-43-0) + <<2α(R),3β>-1S,2S>-1-(2-methyl-3-phenyloxiranyl)-1,2-propanediol (67505-10-6)

Guidance literature:

With titanium(IV) isopropylate; 2-hydroperoxy-2-methyl-1-propanol; 4 A molecular sieve; at 20 ℃; for 1h; other reagents: 2,3-dimethyl-3-hydroperoxy-2-butanol, 2-hydroperoxy-2-phenyl-1-ethanol, m-chloroperoxybenzoic acid, NaHCO₃, dimethyldioxirane;

DOI:10.1021/jo970110x

Reference yield:

(2S,3R)-2,3-Dihydroxy-4-methyl-5-phenylpent-4-ene (67470-70-6) → <<2α(R),3β>-1S,2S>-1-(2-methyl-3-phenyloxiranyl)-1,2-propanediol (67505-10-6) + (1S,2S)-1-((2R,3R)-2-Methyl-3-phenyl-oxiranyl)-propane-1,2-diol

Guidance literature:

With 3,3-dimethyldioxirane; In acetone; at 20 ℃; for 1h; Mechanism; Product distribution; other ene diols and allylic alcohols, other reagents: HOOC(CH₃)2CH₂OH, HOOC(CH₃)2C(CH₃)2OH, HOOC(C₆H₅)CH₂OH, Ti(OiPr)4, molecular sieves 4A, mCPBA/NaHCO₃, tBuOOH, other solvents: CH₂Cl₂, CDCl₃, other reaction time, various reactant ratio;

DOI:10.1021/jo970110x

Reference yield:

<<2α(R),3β>-1S,2S>-1-(2-methyl-3-phenyloxiranyl)-1,2-propanediol (67505-10-6) → Acetic acid (1S,2R)-1-((S)-1-acetoxy-ethyl)-2-hydroxy-2-methyl-3-phenyl-propyl ester

Guidance literature:

Multistep reaction; (i) (acetylation), (ii) H₂, Pd-C;

DOI:10.1039/c39780000299

upstream raw materials:

(2S,3R)-2,3-Dihydroxy-4-methyl-5-phenylpent-4-ene