ethyl 3-((dimethylamino)methylene)-2-oxocyclohexanecarboxylate

Base Information

• Chemical Name: ethyl 3-((dimethylamino)methylene)-2-oxocyclohexanecarboxylate
• CAS No.: 1172638-81-1
• Molecular Formula: C₁₂H₁₉NO₃
• Molecular Weight: 225.288
• Mol file: 1172638-81-1.mol

Synonyms:ethyl 3-((dimethylamino)methylene)-2-oxocyclohexanecarboxylate

Chemical Property of ethyl 3-((dimethylamino)methylene)-2-oxocyclohexanecarboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of ethyl 3-((dimethylamino)methylene)-2-oxocyclohexanecarboxylate

There total 1 articles about ethyl 3-((dimethylamino)methylene)-2-oxocyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + ethyl 2-oxocyclohexane carboxylate (1655-07-8) → ethyl 3-((dimethylamino)methylene)-2-oxocyclohexanecarboxylate (1172638-81-1)

Guidance literature:

In N,N-dimethyl-formamide; at 90 ℃;

DOI:10.1016/j.bmcl.2014.10.010

Reference yield:

ethyl 3-((dimethylamino)methylene)-2-oxocyclohexanecarboxylate (1172638-81-1) + 4-(4-(trifluoromethyl)phenyl)-1H-pyrazol-5-amine (6804-53-1) → C20H18F3N3O2

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; ethanol; at 80 ℃;

DOI:10.1016/j.bmcl.2014.10.010

Reference yield:

ethyl 3-((dimethylamino)methylene)-2-oxocyclohexanecarboxylate (1172638-81-1) → ethyl 9-benzyl-3-(4-(trifluoromethyl)phenyl)-6,7,8,9-tetrahydropyrazolo[1,5-a]quinazoline-9-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol; 1,4-dioxane / 80 °C

2: caesium carbonate / N,N-dimethyl-formamide / 65 °C

With hydrogenchloride; caesium carbonate; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2014.10.010

upstream raw materials:

N,N-dimethyl-formamide dimethyl acetal

ethyl 2-oxocyclohexane carboxylate