5-(2-(4-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)phenyl)vinyl)thiophen-2-carbaldehyde

Base Information

Chemical Name:5-(2-(4-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)phenyl)vinyl)thiophen-2-carbaldehyde
CAS No.:1360702-45-9
Molecular Formula:C₂₇H₂₁NOS
Molecular Weight:407.536
Hs Code.:

Synonyms:5-(2-(4-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)phenyl)vinyl)thiophen-2-carbaldehyde

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Chemical Property of 5-(2-(4-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)phenyl)vinyl)thiophen-2-carbaldehyde

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Technology Process of 5-(2-(4-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)phenyl)vinyl)thiophen-2-carbaldehyde

There total 5 articles about 5-(2-(4-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)phenyl)vinyl)thiophen-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-(2-(4-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)phenyl)vinyl)thiophen

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 1360702-45-9
5-(2-(4-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)phenyl)vinyl)thiophen-2-carbaldehyde

Guidance literature:: 5-(2-(4-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)phenyl)vinyl)thiophen; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 1.66667h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.dyepig.2011.11.002

Reference yield:

: 494-19-9
9,10-dihydrodibenzazepine

: 1360702-45-9
5-(2-(4-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)phenyl)vinyl)thiophen-2-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: 18-crown-6 ether; copper; potassium carbonate / 1,2-dichloro-benzene / 48 h / 180 °C / Inert atmosphere

2.1: trichlorophosphate / 1 h / 0 °C / Inert atmosphere

2.2: 8 h / 80 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3.2: 25 h / 20 °C / Inert atmosphere; Reflux

4.1: n-butyllithium / tetrahydrofuran; hexane / 1.67 h / -78 - 0 °C / Inert atmosphere

4.2: 2 h / -78 - 20 °C / Inert atmosphere

With n-butyllithium; 18-crown-6 ether; potassium tert-butylate; copper; potassium carbonate; trichlorophosphate; In tetrahydrofuran; hexane; 1,2-dichloro-benzene; 1.1: Ullmann condensation / 2.1: Vilsmeier-Haack reaction / 2.2: Vilsmeier-Haack reaction / 3.1: Wittig reaction / 3.2: Wittig reaction;
DOI:10.1016/j.dyepig.2011.11.002

Reference yield:

: 78943-60-9
10,11-dihydro-N-phenyldibenzazepine

: 1360702-45-9
5-(2-(4-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)phenyl)vinyl)thiophen-2-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 1 h / 0 °C / Inert atmosphere

1.2: 8 h / 80 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2.2: 25 h / 20 °C / Inert atmosphere; Reflux

3.1: n-butyllithium / tetrahydrofuran; hexane / 1.67 h / -78 - 0 °C / Inert atmosphere

3.2: 2 h / -78 - 20 °C / Inert atmosphere

With n-butyllithium; potassium tert-butylate; trichlorophosphate; In tetrahydrofuran; hexane; 1.1: Vilsmeier-Haack reaction / 1.2: Vilsmeier-Haack reaction / 2.1: Wittig reaction / 2.2: Wittig reaction;
DOI:10.1016/j.dyepig.2011.11.002