(R,S)-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>carbonyl>-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine methyl ester

Base Information

Chemical Name:(R*,S*)-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>carbonyl>-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine methyl ester
CAS No.:166168-93-0
Molecular Formula:C₄₈H₅₈N₄O₇S₂
Molecular Weight:867.143
Hs Code.:

(R*,S*)-N-<<2-<N-<<2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<(triphenylmethyl)thio>propyl>carbonyl>-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine methyl ester

Synonyms:(R*,S*)-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>carbonyl>-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine methyl ester

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Chemical Property of (R*,S*)-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>carbonyl>-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine methyl ester

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Technology Process of (R*,S*)-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>carbonyl>-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine methyl ester

There total 7 articles about (R*,S*)-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>carbonyl>-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 21947-98-8,87494-13-1
N-tert-butyloxycarbonyl-S-trityl-L-cysteine

: 166168-91-8
(R*)-N-<(2-L-valyl-1,2,3,4-tetrahydro-3-isoquinolinyl)carbonyl>-L-methionine methyl ester

: 166168-93-0
(R*,S*)-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>carbonyl>-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine methyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 16h;
DOI:10.1021/jm950642a

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 166168-93-0
(R*,S*)-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>carbonyl>-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / Bop-Cl, N,N-diisopropylethylamine / CH₂Cl₂ / 24 h / 0 °C

2: 99 percent / 4 N HCl / CH₂Cl₂; dioxane; various solvent(s) / 1 h

3: 67 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, hydroxybenzotriazole, diisopropylethylamine / dimethylformamide / 16 h

With hydrogenchloride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm950642a

Reference yield:

: 2491-18-1
(S)-methyl 2-amino-4-(methylthio)butanoate hydrochloride

: 166168-93-0
(R*,S*)-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>carbonyl>-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NMP, diisopropylethylamine, hydroxybenzotriazole, diisopropylethylamine, 2.) 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / 1.) CH₂Cl₂, 4 deg C, 5 min, 2.) CH₂Cl₂, RT, 16 h

2: 99 percent / 4 N HCl / CH₂Cl₂; various solvent(s); dioxane / 1 h

3: 97 percent / Bop-Cl, N,N-diisopropylethylamine / CH₂Cl₂ / 24 h / 0 °C

4: 99 percent / 4 N HCl / CH₂Cl₂; dioxane; various solvent(s) / 1 h

5: 67 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, hydroxybenzotriazole, diisopropylethylamine / dimethylformamide / 16 h

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm950642a