4-[5-(4-trifluoromethylphenyl)-4,5-dihydro-isoxazol-3-yl]-phenylamine

Base Information

• Chemical Name: 4-[5-(4-trifluoromethylphenyl)-4,5-dihydro-isoxazol-3-yl]-phenylamine
• CAS No.: 1181214-91-4
• Molecular Formula: C₁₆H₁₃F₃N₂O
• Molecular Weight: 306.287
• Mol file: 1181214-91-4.mol

Synonyms:4-[5-(4-trifluoromethylphenyl)-4,5-dihydro-isoxazol-3-yl]-phenylamine

Chemical Property of 4-[5-(4-trifluoromethylphenyl)-4,5-dihydro-isoxazol-3-yl]-phenylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[5-(4-trifluoromethylphenyl)-4,5-dihydro-isoxazol-3-yl]-phenylamine

There total 2 articles about 4-[5-(4-trifluoromethylphenyl)-4,5-dihydro-isoxazol-3-yl]-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

{4-[5-(4-Trifluoromethylphenyl)-4,5-dihydro-isoxazol-3-yl]-phenyl}-carbamic acid tert-butyl ester (1181214-92-5) → 4-[5-(4-trifluoromethylphenyl)-4,5-dihydro-isoxazol-3-yl]-phenylamine (1181214-91-4)

Guidance literature:

{4-[5-(4-Trifluoromethylphenyl)-4,5-dihydro-isoxazol-3-yl]-phenyl}-carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

With potassium hydrogencarbonate; In water; for 0.5h;

Reference yield:

1-trifluoromethyl-4-vinyl-benzene (402-50-6) + [4-(hydroxyiminomethyl)phenyl]carbamic acid tert-butyl ester (170727-03-4) → 4-[5-(4-trifluoromethylphenyl)-4,5-dihydro-isoxazol-3-yl]-phenylamine (1181214-91-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-chloro-succinimide; pyridine / chloroform / 0.17 h / 20 °C

1.2: 5 h / 20 - 45 °C

2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

2.2: 0.5 h

With pyridine; N-chloro-succinimide; trifluoroacetic acid; In dichloromethane; chloroform;

upstream raw materials:

{4-[5-(4-Trifluoromethylphenyl)-4,5-dihydro-isoxazol-3-yl]-phenyl}-carbamic acid tert-butyl ester

1-trifluoromethyl-4-vinyl-benzene

[4-(hydroxyiminomethyl)phenyl]carbamic acid tert-butyl ester