N-[(1R,2S)-4,4-difluoro-2-{[4-(1H-imidazol-2-yl)-2,3-dihydro-1H-pyrrolo[3,2-c]quinolin-1-yl]carbonyl}cyclohexyl]-4-(3-methyl-1H-pyrazol-1-yl)benzamide hydrobromide

Base Information

Chemical Name:N-[(1R,2S)-4,4-difluoro-2-{[4-(1H-imidazol-2-yl)-2,3-dihydro-1H-pyrrolo[3,2-c]quinolin-1-yl]carbonyl}cyclohexyl]-4-(3-methyl-1H-pyrazol-1-yl)benzamide hydrobromide
CAS No.:1304113-28-7
Molecular Formula:BrH*C₃₂H₂₉F₂N₇O₂
Molecular Weight:662.537
Hs Code.:

N-[(1R,2S)-4,4-difluoro-2-{[4-(1H-imidazol-2-yl)-2,3-dihydro-1H-pyrrolo[3,2-c]quinolin-1-yl]carbonyl}cyclohexyl]-4-(3-methyl-1H-pyrazol-1-yl)benzamide hydrobromide

Synonyms:N-[(1R,2S)-4,4-difluoro-2-{[4-(1H-imidazol-2-yl)-2,3-dihydro-1H-pyrrolo[3,2-c]quinolin-1-yl]carbonyl}cyclohexyl]-4-(3-methyl-1H-pyrazol-1-yl)benzamide hydrobromide

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Chemical Property of N-[(1R,2S)-4,4-difluoro-2-{[4-(1H-imidazol-2-yl)-2,3-dihydro-1H-pyrrolo[3,2-c]quinolin-1-yl]carbonyl}cyclohexyl]-4-(3-methyl-1H-pyrazol-1-yl)benzamide hydrobromide

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Technology Process of N-[(1R,2S)-4,4-difluoro-2-{[4-(1H-imidazol-2-yl)-2,3-dihydro-1H-pyrrolo[3,2-c]quinolin-1-yl]carbonyl}cyclohexyl]-4-(3-methyl-1H-pyrazol-1-yl)benzamide hydrobromide

There total 17 articles about N-[(1R,2S)-4,4-difluoro-2-{[4-(1H-imidazol-2-yl)-2,3-dihydro-1H-pyrrolo[3,2-c]quinolin-1-yl]carbonyl}cyclohexyl]-4-(3-methyl-1H-pyrazol-1-yl)benzamide hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1304113-27-6
N-[(1R,2S)-4,4-difluoro-2-{[4-(1H-imidazol-2-yl)-2,3-dihydro-1H-pyrrolo[3,2-c]quinolin-1-yl]carbonyl}cyclohexyl]-4-(3-methyl-1H-pyrazol-1-yl)benzamide

: 1304113-28-7
N-[(1R,2S)-4,4-difluoro-2-{[4-(1H-imidazol-2-yl)-2,3-dihydro-1H-pyrrolo[3,2-c]quinolin-1-yl]carbonyl}cyclohexyl]-4-(3-methyl-1H-pyrazol-1-yl)benzamide hydrobromide

Guidance literature:: With hydrogen bromide; In ethanol; water; ethyl acetate;

Reference yield:

: 813445-18-0
ethyl (R)-8-((1-phenylethyl)amino)-1,4-dioxaspiro[4.5]dec-7-ene-7-carboxylate

: 1304113-28-7
N-[(1R,2S)-4,4-difluoro-2-{[4-(1H-imidazol-2-yl)-2,3-dihydro-1H-pyrrolo[3,2-c]quinolin-1-yl]carbonyl}cyclohexyl]-4-(3-methyl-1H-pyrazol-1-yl)benzamide hydrobromide

Guidance literature:: Multi-step reaction with 12 steps

1.1: sodium tetrahydroborate / isobutyric Acid / 0 - 20 °C

1.2: 2 h / 0 - 10 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 5 h / 50 °C / Inert atmosphere

3.1: sodium carbonate / water; tetrahydrofuran / 20 °C / Cooling with ice

4.1: hydrogenchloride / water; acetone / 20 °C / Cooling with ice

5.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / toluene / 20 °C / Cooling with ice

5.2: 20 °C / Cooling with ice

6.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 4 h / 20 °C

7.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 12 h / 20 °C

8.1: sodium hydroxide; water / methanol / 12 h / 20 °C

9.1: triethylamine; diethyl cyanophosphonate / N,N-dimethyl-formamide / 0 - 20 °C

10.1: ammonia / water; methanol / 12 h / 20 °C

11.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / tetrahydrofuran / 12 h / 45 - 60 °C

12.1: hydrogen bromide / ethyl acetate; ethanol; water

With hydrogenchloride; sodium tetrahydroborate; diethyl cyanophosphonate; ammonia; water; hydrogen bromide; hydrogen; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium hydroxide; (bis-(2-methoxyethyl)amino)sulfur trufluoride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; isobutyric Acid; acetonitrile;

Reference yield:

: 121210-56-8
ethyl 8-hydroxy-1,4-dioxaspiro[4.5]dec-7-ene-7-carboxylate

: 1304113-28-7
N-[(1R,2S)-4,4-difluoro-2-{[4-(1H-imidazol-2-yl)-2,3-dihydro-1H-pyrrolo[3,2-c]quinolin-1-yl]carbonyl}cyclohexyl]-4-(3-methyl-1H-pyrazol-1-yl)benzamide hydrobromide

Guidance literature:: Multi-step reaction with 13 steps

1.1: toluene-4-sulfonic acid / toluene / 17 h / 70 °C / Reflux

2.1: sodium tetrahydroborate / isobutyric Acid / 0 - 20 °C

2.2: 2 h / 0 - 10 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 5 h / 50 °C / Inert atmosphere

4.1: sodium carbonate / water; tetrahydrofuran / 20 °C / Cooling with ice

5.1: hydrogenchloride / water; acetone / 20 °C / Cooling with ice

6.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / toluene / 20 °C / Cooling with ice

6.2: 20 °C / Cooling with ice

7.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 4 h / 20 °C

8.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 12 h / 20 °C

9.1: sodium hydroxide; water / methanol / 12 h / 20 °C

10.1: triethylamine; diethyl cyanophosphonate / N,N-dimethyl-formamide / 0 - 20 °C

11.1: ammonia / water; methanol / 12 h / 20 °C

12.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / tetrahydrofuran / 12 h / 45 - 60 °C

13.1: hydrogen bromide / ethyl acetate; ethanol; water

With hydrogenchloride; sodium tetrahydroborate; diethyl cyanophosphonate; ammonia; water; hydrogen bromide; hydrogen; sodium carbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium hydroxide; (bis-(2-methoxyethyl)amino)sulfur trufluoride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; isobutyric Acid; acetonitrile;