(E)-1-phenyl-5-(3-thienylethynyl)-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde oxime

Base Information

Chemical Name:(E)-1-phenyl-5-(3-thienylethynyl)-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde oxime
CAS No.:1660148-09-3
Molecular Formula:C₁₇H₁₀F₃N₃OS
Molecular Weight:361.347
Hs Code.:

Synonyms:(E)-1-phenyl-5-(3-thienylethynyl)-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde oxime

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-1-phenyl-5-(3-thienylethynyl)-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde oxime

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Technology Process of (E)-1-phenyl-5-(3-thienylethynyl)-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde oxime

There total 2 articles about (E)-1-phenyl-5-(3-thienylethynyl)-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1660148-01-5
1-phenyl-5-(3-thienylethynyl)-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde

: 1660148-09-3
(E)-1-phenyl-5-(3-thienylethynyl)-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde oxime

Guidance literature:: With hydroxylamine hydrochloride; sodium acetate; In ethanol; at 20 ℃; for 1h;
DOI:10.3762/bjoc.10.183

Reference yield:

: 318288-78-7
5‐chloro‐1‐phenyl‐3‐(trifluoromethyl)‐1H‐pyrazole‐4‐carbaldehyde

: 1660148-09-3
(E)-1-phenyl-5-(3-thienylethynyl)-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde oxime

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

2: hydroxylamine hydrochloride; sodium acetate / ethanol / 1 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydroxylamine hydrochloride; sodium acetate; triethylamine; In ethanol; N,N-dimethyl-formamide; 1: |Sonogashira Cross-Coupling;
DOI:10.3762/bjoc.10.183