methyl 3-((tert-butoxycarbonylamino)methyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)isoxazole-5-carboxylate

Base Information

Chemical Name:methyl 3-((tert-butoxycarbonylamino)methyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)isoxazole-5-carboxylate
CAS No.:1417531-67-9
Molecular Formula:C₂₅H₂₅F₃N₂O₅
Molecular Weight:490.479
Hs Code.:

Synonyms:methyl 3-((tert-butoxycarbonylamino)methyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)isoxazole-5-carboxylate

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Chemical Property of methyl 3-((tert-butoxycarbonylamino)methyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)isoxazole-5-carboxylate

Chemical Property:

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Technology Process of methyl 3-((tert-butoxycarbonylamino)methyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)isoxazole-5-carboxylate

There total 10 articles about methyl 3-((tert-butoxycarbonylamino)methyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)isoxazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1070970-28-3
C₇H₁₃ClN₂O₃

: 1417531-63-5
methyl 4-(4'-(trifluoromethyl)biphenyl-4-yl)buta-2,3-dienoate

: 1417531-67-9
methyl 3-((tert-butoxycarbonylamino)methyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)isoxazole-5-carboxylate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 70 ℃; for 3h; Inert atmosphere;

Reference yield:

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1417531-67-9
methyl 3-((tert-butoxycarbonylamino)methyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)isoxazole-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: palladium diacetate; sodium carbonate / 1,2-dimethoxyethane; water / 3 h / Inert atmosphere; Reflux

2: sodium tetrahydroborate; ethanol / 1 h / 20 °C / Cooling with ice

3: phosphorus tribromide / diethyl ether / 1.5 h / 20 °C / Cooling with ice

4: copper(l) iodide; tetra-(n-butyl)ammonium iodide; potassium carbonate / acetonitrile / 4 h / 40 °C / Inert atmosphere

5: triethylamine / N,N-dimethyl-formamide / 3 h / 70 °C / Inert atmosphere

With sodium tetrahydroborate; copper(l) iodide; ethanol; palladium diacetate; phosphorus tribromide; tetra-(n-butyl)ammonium iodide; sodium carbonate; potassium carbonate; triethylamine; In 1,2-dimethoxyethane; diethyl ether; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 1417531-67-9
methyl 3-((tert-butoxycarbonylamino)methyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)isoxazole-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: palladium diacetate; sodium carbonate / 1,2-dimethoxyethane; water / 3 h / Inert atmosphere; Reflux

2: sodium tetrahydroborate; ethanol / 1 h / 20 °C / Cooling with ice

3: phosphorus tribromide / diethyl ether / 1.5 h / 20 °C / Cooling with ice

4: copper(l) iodide; tetra-(n-butyl)ammonium iodide; potassium carbonate / acetonitrile / 4 h / 40 °C / Inert atmosphere

5: triethylamine / N,N-dimethyl-formamide / 3 h / 70 °C / Inert atmosphere

With sodium tetrahydroborate; copper(l) iodide; ethanol; palladium diacetate; phosphorus tribromide; tetra-(n-butyl)ammonium iodide; sodium carbonate; potassium carbonate; triethylamine; In 1,2-dimethoxyethane; diethyl ether; water; N,N-dimethyl-formamide; acetonitrile;