N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-L-ornithine trifluoroacetate

Base Information

Chemical Name:N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-L-ornithine trifluoroacetate
CAS No.:96846-20-7
Molecular Formula:C₂HF₃O₂*2C₂₀H₂₅N₉O₃
Molecular Weight:992.978
Hs Code.:

N<sup>α</sup>-(4-amino-4-deoxy-N<sup>10</sup>-methylpteroyl)-L-ornithine trifluoroacetate

Synonyms:N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-L-ornithine trifluoroacetate

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Chemical Property of N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-L-ornithine trifluoroacetate

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Technology Process of N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-L-ornithine trifluoroacetate

There total 10 articles about N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-L-ornithine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 96846-16-1
N²-<4-<<(2,4-diamino-6-pteridinyl)methyl>methylamino>benzoyl>-N⁵-<(1,1-dimethylethoxy)carbonyl>-2,5-diaminopentanoic acid

: 76-05-1
trifluoroacetic acid

: 96846-20-7
(S)-5-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanoic acid; compound with trifluoro-acetic acid

Guidance literature:: at 0 - 5 ℃; for 1h;
DOI:10.1021/jm00146a008

Reference yield: 55.0%

: 80407-76-7
N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^δ-carbobenzoxy-L-ornithine tert-butyl ester

: 96846-20-7
N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-L-ornithine trifluoroacetate

Guidance literature:: With boron tribromide; In dichloromethane; 1.) -10 deg C, 1 h, 2.) 25 deg C, 2 h;
DOI:10.1021/jm00346a026

Reference yield:

: 7733-29-1,199924-46-4
Z-Orn(Boc)-OH

: 96846-20-7
(S)-5-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanoic acid; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / 5percent Pd/C / methanol; H₂O / 7 h / 25 °C / 2327.2 - 2585.7 Torr

2: 85 percent / (i-Pr)2NEt / dioxane; H₂O / Ambient temperature

3: 100 percent / H₂ / 5percent Pd/C / dioxane / 25 °C / 2316.8 - 2589 Torr

4: 95 percent / N,N-dimethyl-acetamide / 120 h / 20 - 25 °C

5: 96 percent / 1 h / 0 - 5 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl acetamide; water;
DOI:10.1021/jm00146a008