7-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-6,8-difluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylic acid

Base Information

Chemical Name:7-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-6,8-difluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylic acid
CAS No.:1293992-69-4
Molecular Formula:C₃₃H₃₃F₅N₈O₅
Molecular Weight:716.668
Hs Code.:

Synonyms:7-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-6,8-difluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylic acid

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Chemical Property of 7-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-6,8-difluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylic acid

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Technology Process of 7-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-6,8-difluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylic acid

There total 7 articles about 7-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-6,8-difluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: C₂₅H₁₇Cl₂F₅N₆O₃*ClH

: 1293992-69-4
7-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-6,8-difluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: With potassium carbonate; In tetrahydrofuran; for 7h; Reflux;
DOI:10.1016/j.ejmech.2011.01.044

Reference yield:

: 3862-73-5
2,3,4-trifluoroaniline

: 1293992-69-4
7-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-6,8-difluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: 2 h / 110 - 120 °C

2.1: diphenylether / 8 h / 250 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 4 h / Reflux

4.1: hydrogenchloride; water / acetic acid / 2 h / Reflux

5.1: acetonitrile / 7 h / 90 °C

6.1: tetrahydrofuran / 1.5 h / 20 °C

7.1: potassium carbonate / tetrahydrofuran / 7 h / Reflux

With hydrogenchloride; water; sodium hydride; potassium carbonate; In tetrahydrofuran; diphenylether; acetic acid; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2011.01.044

Reference yield:

: 1293992-41-2
6,7,8-trifluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylic acid

: 1293992-69-4
7-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-6,8-difluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 7 h / 90 °C

2: tetrahydrofuran / 1.5 h / 20 °C

3: potassium carbonate / tetrahydrofuran / 7 h / Reflux

With potassium carbonate; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.ejmech.2011.01.044