3-phenyl-1-(2-(4-(trifluoromethyl)phenyl)-1-(3,4,5-trimethoxyphenyl)cyclopropyl)prop-2-yn-1-one

Base Information

Chemical Name:3-phenyl-1-(2-(4-(trifluoromethyl)phenyl)-1-(3,4,5-trimethoxyphenyl)cyclopropyl)prop-2-yn-1-one
CAS No.:1315459-65-4
Molecular Formula:C₂₈H₂₃F₃O₄
Molecular Weight:480.483
Hs Code.:

Synonyms:3-phenyl-1-(2-(4-(trifluoromethyl)phenyl)-1-(3,4,5-trimethoxyphenyl)cyclopropyl)prop-2-yn-1-one

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Chemical Property of 3-phenyl-1-(2-(4-(trifluoromethyl)phenyl)-1-(3,4,5-trimethoxyphenyl)cyclopropyl)prop-2-yn-1-one

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Technology Process of 3-phenyl-1-(2-(4-(trifluoromethyl)phenyl)-1-(3,4,5-trimethoxyphenyl)cyclopropyl)prop-2-yn-1-one

There total 5 articles about 3-phenyl-1-(2-(4-(trifluoromethyl)phenyl)-1-(3,4,5-trimethoxyphenyl)cyclopropyl)prop-2-yn-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 402-50-6
1-trifluoromethyl-4-vinyl-benzene

: 1315459-44-9
1-diazo-4-phenyl-1-(3,4,5-trimethoxyphenyl)but-3-yn-2-one

: 1315459-65-4
3-phenyl-1-(2-(4-(trifluoromethyl)phenyl)-1-(3,4,5-trimethoxyphenyl)cyclopropyl)prop-2-yn-1-one

Guidance literature:: With tetrakis(trifluoroacetato)rhodium(II); In dichloromethane; for 4h; Inert atmosphere; Reflux;
DOI:10.1021/ol2016548

Reference yield:

: 39053-78-6
3,4,5-trimethoxyphenylacetyl chloride

: 1315459-65-4
3-phenyl-1-(2-(4-(trifluoromethyl)phenyl)-1-(3,4,5-trimethoxyphenyl)cyclopropyl)prop-2-yn-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / water; toluene / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.58 h / -78 - 20 °C / Inert atmosphere

2.2: 1.08 h / -78 °C / Inert atmosphere; Cooling with ice

3.1: 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.08 h / 0 °C / Inert atmosphere

4.1: tetrakis(trifluoroacetato)rhodium(II) / dichloromethane / 4 h / Inert atmosphere; Reflux

With n-butyllithium; tetrakis(trifluoroacetato)rhodium(II); 4-acetamidobenzenesulfonyl azide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; hexane; dichloromethane; water; toluene; acetonitrile;
DOI:10.1021/ol2016548

Reference yield:

: 1315459-77-8
N-methoxy-N-methyl-2-(3,4,5-trimethoxyphenyl)acetamide

: 1315459-65-4
3-phenyl-1-(2-(4-(trifluoromethyl)phenyl)-1-(3,4,5-trimethoxyphenyl)cyclopropyl)prop-2-yn-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.58 h / -78 - 20 °C / Inert atmosphere

1.2: 1.08 h / -78 °C / Inert atmosphere; Cooling with ice

2.1: 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.08 h / 0 °C / Inert atmosphere

3.1: tetrakis(trifluoroacetato)rhodium(II) / dichloromethane / 4 h / Inert atmosphere; Reflux

With n-butyllithium; tetrakis(trifluoroacetato)rhodium(II); 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; hexane; dichloromethane; acetonitrile;
DOI:10.1021/ol2016548