{1-[({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester

Base Information

• Chemical Name: {1-[({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester
• CAS No.: 74088-42-9
• Molecular Formula: C₃₃H₂₉Cl₂N₃O₅
• Molecular Weight: 618.516
• Mol file: 74088-42-9.mol

Synonyms:{1-[({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester

Chemical Property of {1-[({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {1-[({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester

There total 6 articles about {1-[({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

(1-{[5-Chloro-3-(2-chloro-phenyl)-1-methyl-1H-indol-2-ylmethyl]-carbamoyl}-2-phenyl-ethyl)-carbamic acid benzyl ester (59179-91-8) → {1-[({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester (74088-42-9)

Guidance literature:

With chromium(VI) oxide; In water; acetic acid; Ambient temperature;

DOI:10.1021/jm00181a013

Reference yield:

ethyl 5-chloro-3-(o-chlorophenyl)-indole-2-carboxylate (24107-07-1) → {1-[({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester (74088-42-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) NaH / 1.) DMF, RT, 1.5 h, 2.) DMF, RT, overnight

2: 98.5 percent / 86percent KOH / ethanol / 2 h / Heating

3: 1.) SOCl₂, 2.) NH₃ (gas) / 1.) reflux, 3 h, 2.) THF, RT, 3 h

4: LiAlH₄ / diethyl ether / a) RT, 10.5 h, b) reflux, 4 h

5: 1.) SOCl₂, HMPA, 2.) Et₃N / 1.) -5 deg C, 10 min, 2.) Et₂O, RT, overnight

6: 58 percent / CrO₃ / acetic acid; H₂O / Ambient temperature

With chromium(VI) oxide; N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; lithium aluminium tetrahydride; thionyl chloride; ammonia; sodium hydride; triethylamine; In diethyl ether; ethanol; water; acetic acid;

DOI:10.1021/jm00181a013

Reference yield:

5-chloro-3-(o-chlorophenyl)-1-methylindole-2-carboxylic acid (74098-80-9) → {1-[({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester (74088-42-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) SOCl₂, 2.) NH₃ (gas) / 1.) reflux, 3 h, 2.) THF, RT, 3 h

2: LiAlH₄ / diethyl ether / a) RT, 10.5 h, b) reflux, 4 h

3: 1.) SOCl₂, HMPA, 2.) Et₃N / 1.) -5 deg C, 10 min, 2.) Et₂O, RT, overnight

4: 58 percent / CrO₃ / acetic acid; H₂O / Ambient temperature

With chromium(VI) oxide; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; thionyl chloride; ammonia; triethylamine; In diethyl ether; water; acetic acid;

DOI:10.1021/jm00181a013

upstream raw materials:

(1-{[5-Chloro-3-(2-chloro-phenyl)-1-methyl-1H-indol-2-ylmethyl]-carbamoyl}-2-phenyl-ethyl)-carbamic acid benzyl ester

ethyl 5-chloro-3-(o-chlorophenyl)-indole-2-carboxylate

5-chloro-3-(o-chlorophenyl)-1-methylindole-2-carboxylic acid

5-chloro-3-(o-chlorophenyl)-1-methylindole-2-carboxamide

Downstream raw materials:

2-Amino-N-({[4-chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-3-phenyl-propionamide